chloroxine

Trade name: capitrol

Small moleculeapproved

Approved

Oct 19, 1976

Chloroxine, a dichloroquinolinol, was first prepared by A. Hebebrand in 1888. It is an antibacterial drug that has been incorporated into shampoos to treat dandruff and seborrheic dermatitis. It has also been used internally as an antidiarrheal and in the lab as an analytical reagent. The drug was withdrawn from the market in the US by unknown reason. — NCATS

Clinical trial activity

0 trials · 0 clinical orgs · 1 marketing orgs

Phase 1

Phase 2

Phase 3

Phase 4

Timeline

1970s

Oct 19, 1976
Squibb — Earliest FDA Approval
Oct 19, 1976
Squibb — NDA Organization

Indications

Approved for

Dermatitis, Seborrheic (approved 1976)

Mechanism of action

DNAINHIBITOR
DNA inhibitor
Generates free radicals causing DNA damage.

Approval history

approvedOct 19, 1976

Chemistry & pharmacology

Loading structure…

SMILES

OC1=C2N=CC=CC2=C(Cl)C=C1Cl

Mol. weight: 214.048 g/mol
Lipinski Ro5: Pass
Rule of 3: No
Chirality: Achiral Molecule
Inorganic: No
Polymer: No
Delivery: Topical
Availability: Discontinued

Oral

Parenteral

Topical

Yes

Sources

Also known as

5,7-dichlor-8-hydroxychinolin
5,7-dichlor-8-hydroxychinolin
5,7-dichloro-8-hydroxyquinoline
5,7-dichloro-8-hydroxyquinoline
5,7-dichloro-8-oxyquinoline
5,7-dichloro-8-oxyquinoline
5,7-dichloro-8-quinolinol
5,7-dichloro-8-quinolinol
5,7-dichloro-8-quinolinol
5,7-dichlorooxine
5,7-dichlorooxine
5,7-dichloroxine
5,7-dichloroxine
capitol
capitrol
capitrol
capitrol
chlofucid
chloroxine
chloroxine
chloroxine
chloroxine
chloroxine
chloroxine
chloroxine
chloroxine
chloroxine
chloroxine
chloroxine
chloroxine hydrofluoride
chloroxyquinoline
chlorquinol
chlorquinol
chlorquinol
chq
chq
clofuzid
dichlorohydroxyquinoline
dichlorohydroxyquinoline
dichloroquine
dichloroquinolinol
dichloroxin
endiaron
quixalin
quixalin

Organizations

Marketing (1)

Organization	Org type	Relationship	Date
Squibb	For profit	NDA	Oct 19, 1976