chlophedianol

Trade name: clofedanol

Small moleculeapproved

Chlophedianol (Clofedanol) is a centrally-acting cough suppressant, although the mechanism of action is not known. It is available in Canada under the trade name Ulone. It is not available in the United States. Chlophedianol (Clofedanol) suppresses the cough reflex by a direct effect on the cough center in the medulla of the brain. It also has local anesthetic and antihistamine properties, and may have anticholinergic effects at high doses. — NCATS

Clinical trial activity

0 trials · 0 clinical orgs · 1 marketing orgs

Phase 1

Phase 2

Phase 3

Phase 4

Timeline

1960s

Jun 1, 1960
3M — First NDA Organization
Jun 1, 1960
3M — NDA Organization

Indications

Approved for

Cough

Mechanism of action

Unspecified targetOTHER
Unknown
Antitussive drug; probable action in the CNS cough centre

Approval history

approved—

Chemistry & pharmacology

Loading structure…

SMILES

CN(C)CCC(O)(c1ccccc1)c1ccccc1Cl

Mol. weight: 289.81 g/mol
Lipinski Ro5: Pass
Rule of 3: No
Chirality: Racemic Mixture
Inorganic: No
Polymer: No
Delivery: Oral
Availability: Discontinued

Oral

Yes

Parenteral

Topical

Sources

Also known as

2-chloro-alpha-(2-dimethylaminoethyl)benzhydrol
baltix
chlophedianol
chlophedianol
chlophedianol
chlophedianol
chlophedianol
chlophedianol
chlophedianol hcl
chlophedianol hcl
chlophedianol hcl
chlophedianol hydrochloride
chlophedianol hydrochloride
chlophedianol hydrochloride
chlophedianol hydrochloride
chlophendianol hydrochloride
clofedanol
clofedanol
clofedanol
clofedanol
clofedanol
clofedanol
clofedanol
clofedanol
clofedanol
clofedanol hcl
clofedanol hcl
clofedanol hcl
clofedanol hydrochloride
clofedanol hydrochloride
clofedanolum
clofedanolum
clofedianolo
clofedianolo
sl-501
sl-501
ulo
ulo
ulo
ulo

Organizations

Marketing (1)

Organization	Org type	Relationship	Date
3M	For profit	NDA	Jun 1, 1960