sodium phosphate p-32
Approved
May 2, 1957
P-32 is a radioactive isotope of phosphorus with a half-life of 14.29 days. Radioactive decay of P-32 produces beta-particles (electrons) which are able to penetrate tissue at a range of 3-8 mm. Phosphate ion P-32 has many applications in medicine and biology. P32 sodium phosphate was approved by the FDA for the treatment of polycythemia vera, chronic myelocytic leukemia, and chronic lymphocytic leukemia. P32-phosphate may also be used in the palliative treatment of selected patients with multiple areas of skeletal metastases. As metabolic uptake of phosphorus is selectively increased in malignant tissues, P-32 was also used for cancer diagnostics. — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 2 marketing orgs
Timeline
1950s
- May 2, 1957
Bracco — Earliest FDA Approval
- May 2, 1957
Bracco — NDA Secondary Org
- May 2, 1957
Bracco — NDA Organization
- Mar 4, 1959
Mallinckrodt — NDA Secondary Org
Indications
Mechanism of action
- Unspecified targetOTHER
Radiopharmaceutical
Mechanism for sodium phosphate P32
- Unspecified targetOTHER
Unknown
Approval history
- approvedMay 2, 1957
Chemistry & pharmacology
SMILES
[O-][32P]([O-])([O-])=O- Mol. weight
- 95.9715 g/mol
- Chirality
- Achiral Molecule
- Inorganic
- Yes
- Polymer
- No
- Delivery
- Parenteral
- Availability
- Discontinued
Oral
No
Parenteral
Yes
Topical
No
Sources
- NCATSN27ADP50ER ↗
- ChEMBLCHEMBL2107525 ↗
- ChEMBLCHEMBL1200676 ↗
Also known as
- 32p
- 32p
- disodium hydrogen phosphate (32p)
- phosphotope
- phosphotope
- phosphotope
- phosphotope
- sodium phosphate (32p)
- sodium phosphate (32p)
- sodium phosphate (32p)
- sodium phosphate p 32
- sodium phosphate p 32
- sodium phosphate p 32
- sodium phosphate p-32
- sodium phosphate p-32
- sodium phosphate p-32
- sodium phosphate p-32
- sodium phosphate p-32
Organizations
Marketing (3)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| Bracco | For profit | NDA2 | May 2, 1957 |
| Bracco | For profit | NDA | May 2, 1957 |
| Mallinckrodt | For profit | NDA2 | Mar 4, 1959 |