sodium phosphate p-32

Small moleculeapproved

Approved

May 2, 1957

P-32 is a radioactive isotope of phosphorus with a half-life of 14.29 days. Radioactive decay of P-32 produces beta-particles (electrons) which are able to penetrate tissue at a range of 3-8 mm. Phosphate ion P-32 has many applications in medicine and biology. P32 sodium phosphate was approved by the FDA for the treatment of polycythemia vera, chronic myelocytic leukemia, and chronic lymphocytic leukemia. P32-phosphate may also be used in the palliative treatment of selected patients with multiple areas of skeletal metastases. As metabolic uptake of phosphorus is selectively increased in malignant tissues, P-32 was also used for cancer diagnostics. — NCATS

Clinical trial activity

0 trials · 0 clinical orgs · 2 marketing orgs

Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0

Timeline

1950s

  1. May 2, 1957

    Bracco — Earliest FDA Approval

  2. May 2, 1957

    Bracco — NDA Secondary Org

  3. May 2, 1957

    Bracco — NDA Organization

  4. Mar 4, 1959

    Mallinckrodt — NDA Secondary Org

Indications

Mechanism of action

  • Unspecified targetOTHER

    Radiopharmaceutical

    Mechanism for sodium phosphate P32

  • Unspecified targetOTHER

    Unknown

Approval history

  • approvedMay 2, 1957

Chemistry & pharmacology

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SMILES

[O-][32P]([O-])([O-])=O
Mol. weight
95.9715 g/mol
Chirality
Achiral Molecule
Inorganic
Yes
Polymer
No
Delivery
Parenteral
Availability
Discontinued

Oral

No

Parenteral

Yes

Topical

No

Sources

Also known as

  • 32p
  • 32p
  • disodium hydrogen phosphate (32p)
  • phosphotope
  • phosphotope
  • phosphotope
  • phosphotope
  • sodium phosphate (32p)
  • sodium phosphate (32p)
  • sodium phosphate (32p)
  • sodium phosphate p 32
  • sodium phosphate p 32
  • sodium phosphate p 32
  • sodium phosphate p-32
  • sodium phosphate p-32
  • sodium phosphate p-32
  • sodium phosphate p-32
  • sodium phosphate p-32

Organizations

Marketing (3)

OrganizationOrg typeRelationshipDate
BraccoFor profitNDA2May 2, 1957
BraccoFor profitNDAMay 2, 1957
MallinckrodtFor profitNDA2Mar 4, 1959