tolazoline

Small moleculeapproved

Approved

Mar 17, 1948

Tolazoline, also known as priscoline, was used in treatment of persistent pulmonary hypertension of the newborn. But that prescription was discontinued. Priscoline given intravenously produces vasodilatation, primarily due to a direct effect on vascular smooth muscle, and cardiac stimulation; the blood pressure response depends on the relative contributions of the two effects. Priscoline usually reduces pulmonary arterial pressure and vascular resistance. The mechanisms of its therapeutic effects are not clear, but is known, that tolazoline is a non-selective competitive α-adrenergic receptor antagonist and it possesses histamine agonist activity. — NCATS

Clinical trial activity

0 trials · 0 clinical orgs · 2 marketing orgs

Phase 1

Phase 2

Phase 3

Phase 4

Timeline

1940s

Mar 17, 1948
Earliest FDA Approval
Mar 17, 1948
Novartis — NDA Secondary Org

Indications

Approved for

Persistent Fetal Circulation Syndrome (approved 1948)

Mechanism of action

Alpha adrenergic receptor 1A and 1BANTAGONIST
Alpha adrenergic receptor 1A and 1B antagonist
- Alpha-1B adrenergic receptor (Adra1b) ↗
- Alpha-1A adrenergic receptor (Adra1a) ↗
- Alpha-1b adrenergic receptor
- Alpha-1a adrenergic receptor

Approval history

approvedMar 17, 1948

Chemistry & pharmacology

Loading structure…

SMILES

c1ccc(CC2=NCCN2)cc1

Mol. weight: 160.22 g/mol
Lipinski Ro5: Pass
Rule of 3: Yes
Chirality: Achiral Molecule
Inorganic: No
Polymer: No
Delivery: Parenteral
Availability: Discontinued

Oral

Parenteral

Yes

Topical

Sources

Also known as

2-benzyl-2-imidazoline
2-benzyl-2-imidazoline
2-benzyl-4,5-imidazoline
2-benzyl-4,5-imidazoline
2-benzylimidazoline
2-benzylimidazoline
4,5-dihydro-2-(phenylmethyl)-1h-imidazole
4,5-dihydro-2-(phenylmethyl)-1h-imidazole
benzalolin
benzazolin
benzazolin
benzazoline
benzazoline hcl
benzazoline hcl
benzolin
benzylimidazoline
imidalin
imidaline
phenylmethylimidazoline
priscol
priscol
priscoline
priscoline
priscoline
priscoline
tcmdc-125842
tcmdc-125842
tolazolin
tolazolin
tolazolina
tolazolina
tolazoline
tolazoline
tolazoline
tolazoline
tolazoline
tolazoline
tolazoline
tolazoline
tolazoline hcl
tolazoline hcl
tolazoline hcl
tolazoline hydrochloride
tolazoline hydrochloride
tolazoline hydrochloride
tolazoline hydrochloride
tolazoline monohydrochloride
tolazoline monohydrochloride
tolazoline monohydrochloride
tolazoline monohydrochloride
tolazoline monohydrochloride
tolazoline monohydrochloride
tolazolinum
tolazolinum
vasodil

Organizations

Marketing (2)

Organization	Org type	Relationship	Date
Ciba	For profit	NDA	—
Novartis	For profit	NDA2	Mar 17, 1948