lactase
Lactase is an enzyme produced by many organisms and is essential to the complete digestion of whole milk. It breaks down the sugar lactose into its component parts, galactose and glucose. Lactase is found in the brush border of the small intestine of humans and other mammals. People deficient in lactase or lacking functional lactase may experience the symptoms of lactose intolerance after consuming milk products. Microbial β-galactosidase can be purchased as a food supplement and is added to milk to produce "lactose-free" milk products. — Wikipedia
Clinical trial activity
10 trials · 15 clinical orgs · 0 marketing orgs
Earliest trial started Jun 1, 2011 (NCT01145586)
Timeline
2010s
- Jan 1, 2011
Earliest Phase 3 Sponsor(trial)
Indications
Studied for
Mechanism of action
- D-lactoseHYDROLYTIC ENZYME
D-lactose hydrolytic enzyme
- lactic acidUnclear
lactic acid unclear
Chemistry & pharmacology
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaLactase ↗
- NCATS37515NWH9U ↗
- ChEMBLCHEMBL2108505 ↗
Also known as
- lactase
- lactase
- lactase
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07088302 | N/A | Aug 30, 2025 | Alexandria University |
| NCT07150884 | N/A | Aug 27, 2025 | Aristotle University of Thessaloniki |
| NCT05100719 | N/A | Sep 30, 2022 | University of Pecs |
| NCT06827405 | N/A | Jun 1, 2022 | RESnTEC, Institute of Research, Ziauddin University |
| NCT05256173 | N/A | Feb 1, 2022 | Xijing Hospital |
| NCT05367453 | N/A | Feb 22, 2021 | Go Fruselva, S.L., Universidad Autonoma de Madrid |
| NCT03814668 | N/A | Nov 5, 2018 | Danisco |
| NCT03659747 | N/A | Sep 11, 2018 | analyze & realize GmbH, Danisco |
| NCT01145339 | Phase 3 | Jul 1, 2011 | Eurofarma Laboratorios S.A., Faculdade de Medicina do ABC, Instituto Alfa de Gastroenterologia de BH, Instituto Goiano de Gastroenterologia |
| NCT01145586 | Phase 3 | Jun 1, 2011 | Albert Einstein Israelite Hospital, Eurofarma Laboratorios S.A., Faculdade de Medicina do ABC, Instituto Alfa de Gastroenterologia de BH, Instituto Goiano de Gastroenterologia |
Organizations
Research & Development (15)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Danisco | For profit | 2 | 2 | 1 | 2018 |
| Eurofarma Laboratorios S.A. | For profit | 2 | 2 | 1 | 2011 |
| Faculdade de Medicina do ABC | Academic/Hospital | 2 | 0 | 1 | 2011 |
| Instituto Alfa de Gastroenterologia de BH | Academic/Hospital | 2 | 0 | 1 | 2011 |
| Instituto Goiano de Gastroenterologia | Academic/Hospital | 2 | 0 | 1 | 2011 |
| Albert Einstein Israelite Hospital | Academic/Hospital | 1 | 0 | 1 | 2011 |
| Alexandria University | Academic/Hospital | 1 | 1 | 1 | 2025 |
| analyze & realize GmbH | For profit | 1 | 0 | 1 | 2018 |
| Aristotle University of Thessaloniki | Academic/Hospital | 1 | 1 | 1 | 2025 |
| Go Fruselva, S.L. | For profit | 1 | 0 | 1 | 2021 |
| RESnTEC, Institute of Research | Academic/Hospital | 1 | 1 | 1 | 2022 |
| Universidad Autonoma de Madrid | Academic/Hospital | 1 | 1 | 1 | 2021 |
| University of Pecs | Academic/Hospital | 1 | 1 | 1 | 2022 |
| Xijing Hospital | Academic/Hospital | 1 | 1 | 1 | 2022 |
| Ziauddin University | Academic/Hospital | 1 | 0 | 1 | 2022 |