nattokinase
Small moleculeexperimental
Nattokinase is an enzyme extracted and purified from a Japanese food called nattō. Nattō is produced by fermentation by adding the bacterium Bacillus subtilis var natto, which also produces the enzyme, to boiled soybeans. While other soy foods contain enzymes, it is only the nattō preparation that contains the specific nattokinase enzyme under the Japan Nattokinase Administration and Ministry of Health, Labour and Welfare. — Wikipedia
Clinical trial activity
9 trials · 17 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
2
Phase 3
0
Phase 4
3
Earliest trial started Jun 1, 2005 (NCT00447434)
Timeline
2010s
- Jan 1, 2012
Earliest Phase 2 Sponsor(trial)
Indications
Approved for
Mechanism of action
- Unspecified targetAntioxidant
antioxidant
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaNattokinase ↗
Also known as
- bsp subtilisin
- nat subtilisin
- nattokinase
- nattokinase
- nattokinase
- subtilisin nat
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07229521 | N/A | Mar 15, 2025 | Taipei Medical University |
| NCT06183307 | N/A | Mar 1, 2024 | Conselho Nacional de Desenvolvimento Científico e Tecnológico, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Fluminense Federal University, Rio de Janeiro State University |
| NCT05200234 | N/A | Jan 13, 2022 | Zhejiang University |
| NCT02913170 | Phase 4 | May 1, 2015 | Yonsei University |
| NCT02080520 | Phase 2 | Apr 1, 2014 | University of Southern California |
| NCT02886507 | Phase 4 | Mar 1, 2012 | JBSL-USA Incorporated, Natural Immune Systems Inc, NIS Labs |
| NCT02862223 | Phase 2 | Mar 1, 2012 | Arthur Andrew Medical, KGK Science Inc. |
| NCT00749801 | N/A | May 1, 2007 | Chimei Medical Center, Chung Chou Institute of Technology, GeneFerm Biotechnology Co., Ltd. |
| NCT00447434 | Phase 4 | Jun 1, 2005 | Changhua Christian Hospital |
Showing 9 of 9 trials
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Organizations
Research & Development (17)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Arthur Andrew Medical | Academic/Hospital | 1 | 0 | 1 | 2012 |
| Changhua Christian Hospital | Academic/Hospital | 1 | 1 | 1 | 2005 |
| Chimei Medical Center | Academic/Hospital | 1 | 1 | 1 | 2007 |
| Chung Chou Institute of Technology | Academic/Hospital | 1 | 0 | 1 | 2007 |
| Conselho Nacional de Desenvolvimento Científico e Tecnológico | Government | 1 | 0 | 1 | 2024 |
| Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | Government | 1 | 0 | 1 | 2024 |
| Fluminense Federal University | Academic/Hospital | 1 | 1 | 1 | 2024 |
| GeneFerm Biotechnology Co., Ltd. | For profit | 1 | 0 | 1 | 2007 |
| JBSL-USA Incorporated | For profit | 1 | 0 | 1 | 2012 |
| KGK Science Inc. | For profit | 1 | 1 | 1 | 2012 |
| Natural Immune Systems Inc | For profit | 1 | 1 | 1 | 2012 |
| NIS Labs | For profit | 1 | 0 | 1 | 2012 |
| Rio de Janeiro State University | Academic/Hospital | 1 | 0 | 1 | 2024 |
| Taipei Medical University | Academic/Hospital | 1 | 1 | 1 | 2025 |
| University of Southern California | Academic/Hospital | 1 | 1 | 1 | 2014 |
| Yonsei University | Academic/Hospital | 1 | 1 | 1 | 2015 |
| Zhejiang University | Academic/Hospital | 1 | 1 | 1 | 2022 |
17 organizations
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