azatadine
Trade name: optimine
Approved
Mar 29, 1977
Azatadine is an antihistamine, which blocks the effects of the naturally occurring chemical histamine in the body. Azatadine is used to treat sneezing; runny nose; itching, watery eyes; hives; rashes; and other symptoms of allergies and the common cold. The antihistamines antagonize those pharmacological effects of histamine, which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release. — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 2 marketing orgs
Timeline
1970s
- Mar 29, 1977
Schering-Plough — Earliest FDA Approval
- Mar 29, 1977
Schering — NDA Secondary Org
- Mar 29, 1977
Schering-Plough — NDA Organization
Indications
Mechanism of action
- Histamine H1 receptorANTAGONIST
HRH1 antagonist
Combination products
trinalin
with pseudoephedrine
Approval history
- approvedMar 29, 1977
Chemistry & pharmacology
SMILES
CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1- Mol. weight
- 290.41 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral
- Availability
- Discontinued
Oral
Yes
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL946 ↗
- WikipediaAzatadine ↗
- NCATS94Z39NID6C ↗
- ChEMBLCHEMBL3544908 ↗
Also known as
- 11-(1-methyl-4-piperidinylidene)-6,11-dihydro-5h-benzo[5,6]cyclohepta[1,2-b]pyridine
- 11-(1-methyl-4-piperidinylidene)-6,11-dihydro-5h-benzo[5,6]cyclohepta[1,2-b]pyridine
- 6,11-dihydro-11-(1-methyl-4-piperidylidene)-5h-benzo(5,6)cyclohepta(1,2-b)pyridine
- 6,11-dihydro-11-(1-methyl-4-piperidylidene)-5h-benzo(5,6)cyclohepta(1,2-b)pyridine
- 6,11-dihydro-11-(1-methyl-4-piperidylidene)-5h-benzo(5,6)cyclohepta(1,2-b)pyridine
- azatadin
- azatadin
- azatadina
- azatadina
- azatadine
- azatadine
- azatadine
- azatadine
- azatadine
- azatadine
- azatadine
- azatadine
- azatadine
- azatadine maleate
- azatadine maleate
- azatadine maleate
- azatadine maleate
- azatadine maleate
- azatadinum
- azatadinum
- azatidine
- azatidine
- azatidine
- azatidine
- azatidine
- idulamine
- idulian
- juste brand of azatadine maleate
- key brand of azatadine maleate
- lergocil
- lergocil
- lergocil
- optimine
- optimine
- optimine
- optimine
- sch-10649
- sch-10649
- schering brand of azatadine maleate
- schering-plough brand of azatadine maleate
- trinalin
- trinalin
- zadine
Organizations
Marketing (2)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| Schering | For profit | NDA2 | Mar 29, 1977 |
| Schering-Plough | For profit | NDA | Mar 29, 1977 |