diphenylpyraline

Trade name: hispril

Small moleculeapproved

Diphenylpyraline is an antihistamine that prevents but does not reverse, responses mediated by histamine alone. Diphenylpyraline antagonizes most of the pharmacological effects of histamine, including urticaria and pruritus. Also, diphenylpyraline may exhibit anticholinergic actions (as do most of the antihistamines) and may thus provide a drying effect on the nasal mucosa. Antihistamines such as diphenylpyraline used in the treatment of allergy act by competing with histamine for H1-receptor sites on effector cells. This reduces the effects of histamine, leading to a temporary reduction of allergy symptoms. — NCATS

Clinical trial activity

0 trials · 0 clinical orgs · 2 marketing orgs

Phase 1

Phase 2

Phase 3

Phase 4

Timeline

1960s

Mar 15, 1960
Smith, Kline & French — First NDA Organization
Mar 15, 1960
Smith, Kline & French — NDA Organization

Indications

Approved for

Mechanism of action

Histamine H1 receptorANTAGONIST
HRH1 antagonist
- Histamine H1 receptor (HRH1) ↗

Approval history

approved—

Chemistry & pharmacology

Loading structure…

SMILES

CN1CCC(OC(c2ccccc2)c2ccccc2)CC1

Mol. weight: 281.4 g/mol
Lipinski Ro5: Pass
Rule of 3: No
Chirality: Achiral Molecule
Inorganic: No
Polymer: No
Delivery: Oral
Availability: Discontinued

Oral

Yes

Parenteral

Topical

Sources

Also known as

1-methyl-4-hydroxypiperidine benzhydryl ether
1-methyl-4-hydroxypiperidine benzhydryl ether
1-methyl-4-piperidyl benzhydryl ether
1-methyl-4-piperidyl benzhydryl ether
4-(benzhydryloxy)-1-methylpiperidine
4-(benzhydryloxy)-1-methylpiperidine
4-(benzhydryloxy)-n-methylpiperidine
4-(benzhydryloxy)-n-methylpiperidine
4-diphenylmethoxy-1-methylpiperidine
difenilpiralina
difenilpiralina
diphenpyraline
diphenylpyralamine
diphenylpyralamine
diphenylpyraline
diphenylpyraline
diphenylpyraline
diphenylpyraline
diphenylpyraline
diphenylpyraline
diphenylpyraline
diphenylpyraline
diphenylpyraline
diphenylpyraline
diphenylpyraline hcl
diphenylpyraline hcl
diphenylpyraline hcl
diphenylpyraline hydrochloride
diphenylpyraline hydrochloride
diphenylpyraline hydrochloride
diphenylpyraline hydrochloride
diphenylpyraline hydrochloride
diphenylpyraline maleate
diphenylpyraline maleate (2:1)
diphenylpyraline teoclate
diphenylpyraline teoclate
diphenylpyralinum
diphenylpyralinum
diphenylpyrilene
hispril
hispril
hispril
hispril
hispril
hispril
histryl
histryl
histryl paed
lergoban
lergoban
lergobine

Organizations

Marketing (2)

Organization	Org type	Relationship	Date
GlaxoSmithKline	For profit	NDA2	—
Smith, Kline & French	For profit	NDA	Mar 15, 1960