verecimon
Small moleculeexperimental
Clinical trial activity
12 trials · 3 clinical orgs · 0 marketing orgs
Phase 1
4
Phase 2
8
Phase 3
4
Phase 4
0
Earliest trial started Aug 1, 2004 (NCT00102921)
Timeline
Indications
Mechanism of action
- C-C chemokine receptor type 9ANTAGONIST
CCR9 antagonist
Phase 3 trials terminated, compound development discontinued due to lack of efficacy and adverse events. Still in ChemoCentryx pipeline, compound on hold. Indication: Crohn¿s disease
Chemistry & pharmacology
Loading structure…
SMILES
CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2cc[n+]([O-])cc2)cc1- Mol. weight
- 444.94 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL2178578 ↗
- ChEMBLCHEMBL3039505 ↗
Also known as
- ccx-282
- ccx282-b
- ccx282-b
- ccx282-b
- gsk1605786
- gsk1605786
- gsk1605786a
- gsk1605786a
- gsk1605786a
- traficet-en
- vercirnon
- vercirnon
- vercirnon
- vercirnon sodium
- vercirnon sodium
- verecimon
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT01827631 | Phase 1 | May 27, 2013 | GlaxoSmithKline |
| NCT01658605 | Phase 2 | Feb 1, 2013 | GlaxoSmithKline |
| NCT01536418 | Phase 3 | Nov 11, 2011 | GlaxoSmithKline |
| NCT01489943 | Phase 1 | Sep 1, 2011 | GlaxoSmithKline |
| NCT01316939 | Phase 3 | May 1, 2011 | GlaxoSmithKline |
| NCT01318993 | Phase 3 | Apr 1, 2011 | GlaxoSmithKline |
| NCT01277666 | Phase 3 | Dec 1, 2010 | GlaxoSmithKline |
| NCT01611805 | Phase 1 | Jul 22, 2010 | GlaxoSmithKline |
| NCT01114607 | Phase 1 | May 1, 2010 | GlaxoSmithKline |
| NCT00540657 | Phase 2 | Oct 1, 2007 | ChemoCentryx, University of Tampere |
| NCT00306215 | Phase 2 | Mar 1, 2006 | ChemoCentryx |
| NCT00102921 | Phase 2 | Aug 1, 2004 | ChemoCentryx |
Showing 12 of 12 trials
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Organizations
Research & Development (3)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| GlaxoSmithKline | For profit | 9 | 9 | 3 | 2010 |
| ChemoCentryx | For profit | 3 | 3 | 1 | 2004 |
| University of Tampere | Academic/Hospital | 1 | 0 | 1 | 2007 |
3 organizations
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