thallous chloride ti 201
Approved
Dec 16, 1977
Thallous chloride (also known as Thallium(I) chloride) is a chemical compound with the formula TlCl. Thallous Chloride Tl 201 Injection is a diagnostic radiopharmaceutical indicated for: Myocardial perfusion imaging with planar scintigraphy or single-photon emission computed tomography (SPECT) for the diagnosis of coronary artery disease by localization of: Non-reversible defects (myocardial infarction) which may have prognostic value regarding survival. Reversible defects (myocardial ischemia) when used in conjunction with exercise or pharmacologic stress. Localization of sites of parathyroid hyperactivity pre- and post-operatively in patients with elevated serum calcium and parathyroid hormone levels. — NCATS
Clinical trial activity
1 trials · 1 clinical orgs · 6 marketing orgs
Earliest trial started Jul 1, 2006 (NCT00381316)
Timeline
1970s
- Dec 16, 1977
Lantheus Medical Imaging — Earliest FDA Approval
- Dec 16, 1977
Lantheus Medical Imaging — NDA Secondary Org
- Dec 16, 1977
Lantheus Medical Imaging — NDA Organization
- Oct 23, 1979
Curium Pharma — NDA Secondary Org
1980s
- Feb 1, 1982
General Electric — NDA Secondary Org
- Dec 30, 1982
Bracco — NDA Secondary Org
2000s
- Nov 21, 2001
Trace Life — Marketing Organization
- Nov 9, 2006
Mallinckrodt — Marketing Organization
- Nov 9, 2006
Curium Pharma — Marketing Organization
Indications
Studied for
Mechanism of action
- Unspecified targetRadiopharmaceutical
Radiopharmaceutical
Approval history
- approvedPriority reviewDec 16, 1977
Chemistry & pharmacology
SMILES
[201Tl+]- Mol. weight
- 200.97080377 g/mol
- Chirality
- Achiral Molecule
- Inorganic
- Yes
- Polymer
- No
- Delivery
- Parenteral
- Availability
- Prescription Only
- Imaging
- 201-thallium
Oral
No
Parenteral
Yes
Topical
No
Sources
- ChEMBLCHEMBL2110567 ↗
- NCATS4877X14G4C ↗
- ChEMBLCHEMBL4302512 ↗
- ChEMBLCHEMBL1200535 ↗
Also known as
- 201tl
- 201tl
- thallium-201 chloride
- thallium-201 monochloride
- thallium (201tl) chloride
- thallium chloride
- thallium chloride
- thallium chloride
- thallium chloride (201tl) injection
- thallium chloride, (201)tl-labeled
- thallium chloride, (203)tl,(35)cl-labeled
- thallium chloride, (203)tl,(37)cl-labeled
- thallium chloride, (205)tl,(35)cl-labeled
- thallium chloride, (205)tl,(37)cl-labeled
- thallium(i) chloride
- thallium(i) chloride
- thallium monochloride
- thallium monochloride
- thallium monochloride
- thallous chloride
- thallous chloride
- thallous chloride
- thallous chloride
- thallous chloride
- thallous chloride ti 201
- thallous chloride tl 201
- thallous chloride tl 201
- thallous chloride tl-201
- thallous chloride tl-201
- thallous chloride tl-201
- thallous chloride tl-201
- thallous chloride tl-201
- thallous chloride tl-201
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT00381316 | Phase 4 | Jul 1, 2006 | General Electric |
Organizations
Research & Development (1)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| General Electric | For profit | 1 | 1 | 1 | 2006 |
Marketing (8)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| Bracco | For profit | NDA2 | Dec 30, 1982 |
| Curium Pharma | For profit | NDA2 | Oct 23, 1979 |
| Curium Pharma | For profit | MKTG | Nov 9, 2006 |
| General Electric | For profit | NDA2 | Feb 1, 1982 |
| Lantheus Medical Imaging | For profit | NDA2 | Dec 16, 1977 |
| Lantheus Medical Imaging | For profit | NDA | Dec 16, 1977 |
| Mallinckrodt | For profit | MKTG | Nov 9, 2006 |
| Trace Life | For profit | MKTG | Nov 21, 2001 |