technetium-99m mebrofenin
Trade name: Hepatolite
Small moleculeapprovedImaging agent
Approved
Mar 16, 1982
Clinical trial activity
1 trials · 2 clinical orgs · 3 marketing orgs
Phase 1
1
Phase 2
0
Phase 3
0
Phase 4
0
Earliest trial started Apr 1, 2015 (NCT02235233)
Timeline
1980s
- Mar 16, 1982
Sun Pharmaceuticals — Earliest FDA Approval
- Mar 16, 1982
Pharmalucence — NDA Secondary Org
- Mar 16, 1982
Sun Pharmaceuticals — Marketing Organization
- Mar 16, 1982
Sun Pharmaceuticals — NDA Secondary Org
- Mar 16, 1982
Sun Pharmaceuticals — NDA Organization
- Jan 21, 1987
Bracco — NDA Secondary Org
2010s
- Jan 1, 2015
Earliest Phase 1 Sponsor(trial)
Indications
Approved for
Studied for
Mechanism of action
- contrast mediumRadiopaque
contrast medium radiopaque
Approval history
- approvedPriority reviewMar 16, 1982
Chemistry & pharmacology
Loading structure…
SMILES
Cc1cc(C)c(NC(=O)CN(CC(=O)O)CC(=O)O)c(C)c1Br- Mol. weight
- 486.14 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
- Delivery
- Parenteral
- Availability
- Prescription Only
- Imaging
- 99-technetium
Oral
No
Parenteral
Yes
Topical
No
Sources
- ChEMBLCHEMBL2110575 ↗
- ChEMBLCHEMBL2110555 ↗
- ChEMBLCHEMBL1605443 ↗
- ChEMBLCHEMBL1200923 ↗
- ChEMBLCHEMBL1200421 ↗
Also known as
- 99mtc-disida
- 99mtc-disida
- 99mtc-disofenin
- 99mtc-disofenin
- 99mtc mebrofenin
- bis(2-[[2-(3-bromo-2,4,6-trimethylanilino)-2-oxoethyl]-(carboxymethyl)amino]acetate) technetium
- bis(2-[[2-(3-bromo-2,4,6-trimethylanilino)-2-oxoethyl]-(carboxymethyl)amino]acetate) technetium
- choletec
- choletec
- choletec
- choletec
- hepatolite
- hepatolite
- hepatolite
- mebrofenin
- mebrofenin
- mebrofenin
- mebrofenin
- mebrofenin
- tc 99m mebrofenin
- technetium-99m-diisopropyliminodiacetic acid
- technetium-99m-diisopropyliminodiacetic acid
- technetium-99m disofenin
- technetium-99m disofenin
- technetium-99m mebrofenin
- technetium (99mtc) disofenin
- technetium (99mtc) disofenin
- technetium (99mtc) disofenin
- technetium (99mtc) mebrofenin
- technetium (99mtc) mebrofenin
- technetium (99mtc) mebrofenin
- technetium disofenin
- technetium mebrofenin
- technetium tc 99m diisopropyl-iminodiacetic acid
- technetium tc 99m diisopropyl-iminodiacetic acid
- technetium tc 99m disida
- technetium tc 99m disida
- technetium tc 99m disofenin
- technetium tc 99m disofenin
- technetium tc 99m disofenin
- technetium tc-99m disofenin
- technetium tc-99m disofenin
- technetium tc-99m disofenin kit
- technetium tc-99m disofenin kit
- technetium tc 99m mebrofenin
- technetium tc 99m mebrofenin
- technetium tc 99m mebrofenin
- technetium tc 99m mebrofenin
- technetium tc 99m mebrofenin
- technetium tc-99m mebrofenin
- technetium tc-99m mebrofenin
- technetium tc-99m mebrofenin
- technetium tc-99m mebrofenin
- technetium tc-99m mebrofenin kit
- technetium tc-99m mebrofenin kit
- technetium tc-99m mebrofenin kit
- technetium tc-99m mebrofenin kit
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT02235233 | Phase 1 | Apr 1, 2015 | National Institute of General Medical Sciences (NIGMS), University of North Carolina at Chapel Hill |
Showing 1 of 1 trials
Page 1 / 1
Organizations
Research & Development (2)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| National Institute of General Medical Sciences (NIGMS) | Government | 1 | 0 | 1 | 2015 |
| University of North Carolina at Chapel Hill | Academic/Hospital | 1 | 1 | 1 | 2015 |
2 organizations
Page 1 / 1
Marketing (5)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| Bracco | For profit | NDA2 | Jan 21, 1987 |
| Pharmalucence | For profit | NDA2 | Mar 16, 1982 |
| Sun Pharmaceuticals | For profit | MKTG | Mar 16, 1982 |
| Sun Pharmaceuticals | For profit | NDA2 | Mar 16, 1982 |
| Sun Pharmaceuticals | For profit | NDA | Mar 16, 1982 |