sulfoxone
Trade name: Diasone
Small moleculeapproved
Approved
Jun 1, 1944
Sulfoxone is a water-soluble sulfone and is a competitive inhibitor of the bacterial enzyme dihydropteroate synthetase. Sulfoxone under the brand name Diasone was used as an antileprosy drug, for treatment of dermatitis herpetiformis, and to treat pulmonary tuberculosis. Presently, usage of diasone has been discontinued. — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 2 marketing orgs
Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0
Timeline
1940s
- Jun 1, 1944
Earliest FDA Approval
1970s
- May 24, 1974
AbbVie — NDA Secondary Org
Indications
Mechanism of action
- Dihydropteroate synthase 1INHIBITOR
folP1 inhibitor
Approval history
- approvedJun 1, 1944
Chemistry & pharmacology
Loading structure…
SMILES
O=S(O)CNc1ccc(S(=O)(=O)c2ccc(NCS(=O)O)cc2)cc1- Mol. weight
- 404.49 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Racemic Mixture
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral
- Availability
- Discontinued
Oral
Yes
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL1570 ↗
- WikipediaSulfoxone ↗
- NCATS0G3C18OH4D ↗
- ChEMBLCHEMBL1200580 ↗
Also known as
- aldapsone
- aldesulfone
- aldesulfone
- aldesulfone
- aldesulfone
- aldesulfone sodium
- aldesulfone sodium
- aldesulfone sodium
- aldesulfone sodium
- aldesulfone sodium
- aldesulfon sodium
- aldesulphone
- aldesulphone
- diasone
- diasone
- diasone
- diasone
- diasone sodium
- diasone sodium
- diasone sodium
- sodium aldesulphone
- sodium sulfoxone
- sodium sulfoxone
- sodium sulfoxone
- sulfoxone
- sulfoxone
- sulfoxone
- sulfoxone
- sulfoxone
- sulfoxone
- sulfoxone, disodium salt
- sulfoxone sodium
- sulfoxone sodium
- sulfoxone sodium
- sulfoxone sodium
- sulfoxone sodium
- sulfoxone sodium