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sulfadimethoxine sodium

Small moleculeexperimental

Clinical trial activity

0 trials · 0 clinical orgs · 0 marketing orgs

Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0

Mechanism of action

  • Bacterial dihydropteroate synthaseINHIBITOR

    folP inhibitor

    Bacteria and some protozoa are unable to obtain folic acid from the environment, and must synthesize it by converting PABA (para-aminobenzoate) to dihydropteroate using the enzyme dihydropteroate synthase. Sulfadimethoxine, being structurally similar to PABA, acts as a competitive inhibitor. It binds to the enzyme's active site and prevents the synthesis of folic acid from progressing. Folic acid is necessary for these organisms to produce nucleic acids, which are required for cell division. Thus, it has a microbiostatic effect rather than a microbiocidal one, and has the strongest effect in the beginning stages of an infection, when the pathogen is rapidly dividing.

Chemistry & pharmacology

Loading structure…

SMILES

COc1cc([N-]S(=O)(=O)c2ccc(N)cc2)nc(OC)n1.[Na+]
Mol. weight
332.32 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Achiral Molecule
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • sulfadimethoxine sodium
  • sulfadimethoxine sodium