methylatropinium

Small moleculeexperimental

Methylatropine (methylatroponium) is a belladonna derivative. In 1902 the Bayer Company introduced atropine methonitrate, a quaternary ammonium salt of atropine (Eumydrin), as a mydriatic for dilation of the pupil during ophthalmic examination. Due to its highly polar nature it penetrates less readily into the central nervous system than atropine and was therefore introduced for relieving pyloric spasms in infants. Atropine methyl nitrate is a muscarinic acetylcholine receptor antagonist that does not cross the blood-brain barrier. Atropine methyl nitrate has been used for its peripheral muscarinic effects (targeting the bladder, respiratory tract, and to block parasympathetic signaling to the heart, among others) and to separate central from peripheral nervous system effects, or to protect against peripheral side effects when using muscarinics that do cross the blood brain barrier. — NCATS

Clinical trial activity

0 trials · 0 clinical orgs · 0 marketing orgs

Phase 1

Phase 2

Phase 3

Phase 4

Indications

Approved for

Chemistry & pharmacology

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SMILES

C[N+]1(C)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(CO)c1ccccc1)C2

Mol. weight: 304.41 g/mol
Lipinski Ro5: Pass
Rule of 3: No
Chirality: Racemic Mixture
Inorganic: No
Polymer: No

Oral

Parenteral

Topical

Sources

Also known as

8-methylatropinium nitrate
atropine iodomethylate
atropine methobromide
atropine methonitrate
atropine methonitrate
atropine methonitrate
atropine methonitrate
atropine methylbromide
methylatropine
methylatropine
methylatropine
methylatropine
methylatropine
methylatropine
methyl atropine
methylatropine bromide
methylatropine, endo-3(r)-isomer
methylatropine, endo-3(s)-isomer
methylatropine iodide
methylatropine iodide, 3h-labeled, (endo-(+-))-isomer
methylatropine iodide, (endo-3(r))-isomer
methylatropine iodide, (endo-3(s))-isomer
methylatropine iodide, (endo-(+-))-isomer
methylatropine nitrate
methylatropine nitrate
methylatropine nitrate
methylatropine nitrate
methylatropine nitrate, (endo-(+-))-isomer
methylatropine nitrite, (endo-(+-))-isomer
methylatropine sulfate (2:1), (endo-(+-))-isomer
methylatropinium
n-methylatropine