Radiopharmaceutical

Small moleculeapproved

Approved

Jun 12, 1980

Krypton Kr 81m is radiolabeled noble gas suitable only for inhalation in diagnostic studies. Krypton Kr 81m used for Imaging ventilated regions of the lung, Combined with pulmonary perfusion scintigraphy for diagnosis of pulmonary embolism and other conditions. Krypton Kr 81m diffuses easily, passing through cell membranes and exchanging freely between blood and tissue. It is distributed in the lungs in a manner similar to air, thus representing the regions of the lung that are aerated. The gamma photons of krypton Kr 81m can then be employed to obtain counts per minute per lung or region of the lung, or to display their distribution as a scan. — NCATS

Clinical trial activity

0 trials · 0 clinical orgs · 1 marketing orgs

Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0

Timeline

1980s

  1. Jun 12, 1980

    General Electric — Earliest FDA Approval

  2. Jun 12, 1980

    General Electric — NDA Secondary Org

  3. Jun 12, 1980

    General Electric — NDA Organization

Indications

Mechanism of action

Approval history

  • approvedPriority reviewJun 12, 1980

Chemistry & pharmacology

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SMILES

[Kr]
Mol. weight
83.8 g/mol
Chirality
Achiral Molecule
Inorganic
Yes
Polymer
No
Delivery
Topical
Availability
Discontinued
Payload
81-krypton

Oral

No

Parenteral

No

Topical

Yes

Sources

Also known as

  • 81kr
  • 81mkr
  • 81mkr
  • kr 81
  • krypton
  • krypton
  • krypton-81
  • krypton-81m
  • krypton (81m kr)
  • krypton (81mkr)
  • krypton (81mkr) gas
  • krypton (81mkr) gas
  • krypton (81mkr) gas
  • krypton (81mkr) gas
  • krypton kr 81m
  • krypton kr 81m
  • krypton kr 81m
  • krypton, kr-81m
  • krypton, kr-81m
  • krypton, kr-81m
  • krypton kr 81 m gas generator
  • mpi krypton 81m generator
  • mpi krypton 81m generator
  • mpi krypton 81m generator

Organizations

Marketing (2)

OrganizationOrg typeRelationshipDate
General ElectricFor profitNDA2Jun 12, 1980
General ElectricFor profitNDAJun 12, 1980