Radiopharmaceutical
Approved
Jun 12, 1980
Krypton Kr 81m is radiolabeled noble gas suitable only for inhalation in diagnostic studies. Krypton Kr 81m used for Imaging ventilated regions of the lung, Combined with pulmonary perfusion scintigraphy for diagnosis of pulmonary embolism and other conditions. Krypton Kr 81m diffuses easily, passing through cell membranes and exchanging freely between blood and tissue. It is distributed in the lungs in a manner similar to air, thus representing the regions of the lung that are aerated. The gamma photons of krypton Kr 81m can then be employed to obtain counts per minute per lung or region of the lung, or to display their distribution as a scan. — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 1 marketing orgs
Timeline
1980s
- Jun 12, 1980
General Electric — Earliest FDA Approval
- Jun 12, 1980
General Electric — NDA Secondary Org
- Jun 12, 1980
General Electric — NDA Organization
Indications
Mechanism of action
- contrast mediumRadiopaque
contrast medium radiopaque
Approval history
- approvedPriority reviewJun 12, 1980
Chemistry & pharmacology
SMILES
[Kr]- Mol. weight
- 83.8 g/mol
- Chirality
- Achiral Molecule
- Inorganic
- Yes
- Polymer
- No
- Delivery
- Topical
- Availability
- Discontinued
- Payload
- 81-krypton
Oral
No
Parenteral
No
Topical
Yes
Sources
- ChEMBLCHEMBL1233877 ↗
- NCATS68QN45K12N ↗
- ChEMBLCHEMBL1201096 ↗
Also known as
- 81kr
- 81mkr
- 81mkr
- kr 81
- krypton
- krypton
- krypton-81
- krypton-81m
- krypton (81m kr)
- krypton (81mkr)
- krypton (81mkr) gas
- krypton (81mkr) gas
- krypton (81mkr) gas
- krypton (81mkr) gas
- krypton kr 81m
- krypton kr 81m
- krypton kr 81m
- krypton, kr-81m
- krypton, kr-81m
- krypton, kr-81m
- krypton kr 81 m gas generator
- mpi krypton 81m generator
- mpi krypton 81m generator
- mpi krypton 81m generator
Organizations
Marketing (2)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| General Electric | For profit | NDA2 | Jun 12, 1980 |
| General Electric | For profit | NDA | Jun 12, 1980 |