gluconolactone

Small moleculeapprovedOrphan Drug ^FDA

Approved

Oct 2, 1990

Gluconolactone, a lactone of D-glucuronic acid, is a food additive with the E number E575. Gluconolactone is commonly found in honey, fruit juices, wine. In medcine, gluconolactone is used as a component of irrigation solution Renacidin for dissolution of bladder calculi of the struvite or apatite variety, and to prevent or minimize encrustations of indwelling urinary tract catheters. — NCATS

Clinical trial activity

0 trials · 0 clinical orgs · 1 marketing orgs

Phase 1

Phase 2

Phase 3

Phase 4

Timeline

1980s

Aug 28, 1989
Orphan Drug Designation

1990s

Oct 2, 1990
United Guardian — Earliest FDA Approval
Oct 2, 1990
United Guardian — NDA Secondary Org
Oct 2, 1990
United Guardian — NDA Organization

Indications

Approved for

Mechanism of action

UnclearUnclear
Unclear unclear

Combination products

renacidin
with magnesium carbonate, citric acid

Approval history

approvedPriority reviewOct 2, 1990

Chemistry & pharmacology

Loading structure…

SMILES

OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O

Mol. weight: 178.14 g/mol
Lipinski Ro5: Pass
Rule of 3: No
Chirality: Single Stereoisomer
Inorganic: No
Polymer: No
Availability: Prescription Only

Oral

Parenteral

Topical

Sources

Also known as

1,5-d-gluconolactone
1,5-d-gluconolactone
1,5-gluconolactone
1,5-gluconolactone
beta-glucono-1,5-lactone
delta-gluconolactone
delta-gluconolactone
delta-gluconolactone
delta-gluconolactone
d-gluconic acid delta-lactone
d-gluconic acid delta-lactone
d-gluconic acid-delta-lactone
d-glucono-1,5-lactone
d-glucono-1,5-lactone
d-gluconolactone
d-threo-aldono-1,5-lactone
d-threo-aldono-1,5-lactone
e575
e575
gdl
gdl
gdl (gluconate)
gluconic acid lactone
gluconic acid lactone
glucono delta-lactone
glucono delta-lactone
glucono delta-lactone
glucono-delta-lactone
glucono-delta-lactone
glucono-delta-lactone
gluconolactone
gluconolactone
gluconolactone
gluconolactone
gluconolactone
gluconolactone
gluconolactone
gulonic acid gamma-lactone

Organizations

Marketing (2)

Organization	Org type	Relationship	Date
United Guardian	For profit	NDA2	Oct 2, 1990
United Guardian	For profit	NDA	Oct 2, 1990