gamma-glutamyl-s-(benzyl)-cysteinyl-r(-)-phenylglycine diethyl ester
Small moleculeexperimental
Clinical trial activity
8 trials · 1 clinical orgs · 0 marketing orgs
Phase 1
3
Phase 2
7
Phase 3
0
Phase 4
0
Earliest trial started Apr 1, 2002 (NCT00035867)
Timeline
Indications
Mechanism of action
- Glutathione S-transferase PiINHIBITOR
GSTP1 inhibitor
Ezatiostat is metabolized to TLK117. TLK117 selectively binds to and disrupts the interaction of GST P1-1 with JNK.
Chemistry & pharmacology
Loading structure…
SMILES
CCOC(=O)[C@@H](N)CCC(=O)N[C@@H](CSCc1ccccc1)C(=O)N[C@@H](C(=O)OCC)c1ccccc1- Mol. weight
- 529.66 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL2110585 ↗
- ChEMBLCHEMBL2103810 ↗
Also known as
- ezatiostat
- ezatiostat
- ezatiostat
- ezatiostat hcl
- ezatiostat hcl
- ezatiostat hydrochloride
- ezatiostat hydrochloride
- ezatiostat hydrochloride
- ezatiotsat
- gamma-glu-s-bzcys-phgly diethyl ester
- gamma-glutamyl-s-(benzyl)cysteinyl-phenylglycine diethyl ester
- gamma-glutamyl-s-(benzyl)-cysteinyl-r(-)-phenylglycine diethyl ester
- gamma-glutamyl-s-(benzyl)-cysteinyl-r(-)-phenylglycine diethyl ester
- t.199
- telintra
- telintra
- telintra
- ter199
- ter199
- ter 199
- ter-199
- tlk117
- tlk 117
- tlk-117
- tlk199
- tlk199
- tlk199
- tlk199
- tlk 199
- tlk-199
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT01459159 | Phase 2 | Oct 1, 2011 | Telik |
| NCT01422486 | Phase 2 | Oct 1, 2011 | Telik |
| NCT01062152 | Phase 1 | Nov 1, 2009 | Telik |
| NCT00909584 | Phase 2 | Apr 1, 2009 | Telik |
| NCT00701870 | Phase 2 | Oct 1, 2008 | Telik |
| NCT00700206 | Phase 2 | May 1, 2008 | Telik |
| NCT00280631 | Phase 1/Phase 2 (Phase 2) | Feb 1, 2006 | Telik |
| NCT00035867 | Phase 1/Phase 2 (Phase 2) | Apr 1, 2002 | Telik |
Showing 8 of 8 trials
Page 1 / 1
Organizations
Research & Development (1)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Telik | For profit | 8 | 8 | 2 | 2002 |
1 organizations
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