metocurine iodide

Trade name: metubine

Small moleculeapproved

Approved

Jan 4, 1949

Metocurine, also known as dimethyltubocurarine, is a non-depolarizing muscle relaxant through the neuromuscular blockade. It antagonizes the neurotransmitter action of acetylcholine by binding competitively with cholinergic receptor sites on the motor end-plate. Patients chronically receiving anticonvulsants are relatively resistant to metocurine. — NCATS

Clinical trial activity

0 trials · 0 clinical orgs · 2 marketing orgs

Phase 1

Phase 2

Phase 3

Phase 4

Timeline

1940s

Jan 4, 1949
Earliest FDA Approval
Jan 4, 1949
Eli Lilly — Marketing Organization

1950s

Aug 28, 1951
Eli Lilly — First NDA Organization
Aug 28, 1951
Eli Lilly — NDA Organization

Indications

Approved for

Muscle Relaxation

Mechanism of action

Muscle-type nicotinic acetylcholine receptorANTAGONIST
Muscle-type nicotinic acetylcholine receptor antagonist

Approval history

approvedJan 4, 1949

Chemistry & pharmacology

Loading structure…

SMILES

COc1ccc2cc1Oc1cc3c(cc1OC)CC[N+](C)(C)[C@H]3Cc1ccc(cc1)Oc1c(OC)c(OC)cc3c1[C@@H](C2)[N+](C)(C)CC3

Mol. weight: 652.83 g/mol
Lipinski Ro5: 2 violation(s)
Rule of 3: No
Chirality: Single Stereoisomer
Inorganic: No
Polymer: No
Delivery: Parenteral
Availability: Discontinued

Oral

Parenteral

Yes

Topical

Sources

Also known as

dimethylchondrocurarine
dimethylcurarine dimethochloride
dimethylcurine
dimethyl dl-curine dimethochloride
dimethyl-l-curine dimethochloride
dimethyl-l-curine dimethoiodide
dimethyltubocurarine
dimethyltubocurarine
dimethyltubocurarine
dimethyltubocurarine
dimethyltubocurarine
dimethyltubocurarine chloride
dimethyltubocurarine chloride, 14c-labeled
dimethyltubocurarine hydrobromide
dimethyltubocurarine hydrochloride
dimethyltubocurarine hydroiodide
dimethyl tubocurarine iodide
dimethyl tubocurarine iodide
dimethyl tubocurarine iodide
dimethyltubocurarine iodide
dimethyltubocurarine iodide
dimethyltubocurarine iodide
dimethyltubocurarinium
dimethyltubocurarinium
dimethyltubocurarinium
dimethyltubocurarinium
dimethyltubocurarinium chloride
dimethyltubocurarinium iodide
dimethyltubocurarinium iodide
dimetiltubocurarinio, ioduro de
dimetiltubocurarinio, ioduro de
dmcdm
metocurine
metocurine
metocurine
metocurine
metocurine
metocurine
metocurine, (1'alpha)-isomer
metocurine, (1beta)-isomer
metocurine dichloride
metocurine dichloride, (1'alpha)-isomer
metocurine dichloride(1alpha)-isomer
metocurine dichloride, (1beta)-(+-)-isomer
metocurine dihydroxide
metocurine diiodide
metocurine diiodide, (1beta)-isomer
metocurine diiodide, (1beta)-(+-)-isomer
metocurine iodide
metocurine iodide
metocurine iodide
metocurine iodide
metocurine iodide
metocurine iodide
metocurine iodide
metocurini iodidum
metocurini iodidum
metokuriinijodidi
metokuriinijodidi
metokurinjodid
metokurinjodid
metubine
metubine iodide
metubine iodide
(+)-o,o'-dimethylchondrocurarine di-iodide
(+)-o,o'-dimethylchondrocurarine di-iodide
trimethyltubocurarine iodide
trimethyltubocurarine iodide
trimethyltubocurarine iodide
trimethyltubocurarine iodide
trimethyltubocurarine iodide

Organizations

Marketing (3)

Organization	Org type	Relationship	Date
Athenex, Inc.	For profit	MKTG	—
Eli Lilly	For profit	NDA	Aug 28, 1951
Eli Lilly	For profit	MKTG	Jan 4, 1949