dihydroergocristine mesylate
Small moleculeexperimental
Dihydroergocristine is an ergot alkaloid that has an partial agonist activity on dopaminergic and alpha-adrenergic receptors and antagonist activity on serotonin receptors. The drug was approved by FDA in combination with other alkaloids (dihydroergocornine, dihydro-alpha-ergocryptine and dihydro-beta-ergocryptine mesylate salts) under the name Hydergine for the treatment of dimentia and cerebrovascular insufficiency. — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0
Indications
Chemistry & pharmacology
Loading structure…
SMILES
CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O- Mol. weight
- 611.74 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL601773 ↗
- NCATS05D48LUM4Z ↗
- ChEMBLCHEMBL1255837 ↗
Also known as
- 9,10-dihydroergocristine
- dihydroergocristin
- dihydroergocristine
- dihydroergocristine
- dihydroergocristine
- dihydroergocristine
- dihydroergocristine
- dihydroergocristine
- dihydroergocristine mesilate
- dihydroergocristine mesylate
- gnf-pf-3462
- gnf-pf-3462