dequalinium dichloride
Clinical trial activity
2 trials · 2 clinical orgs · 0 marketing orgs
Earliest trial started Jan 1, 2007 (NCT01125410)
Timeline
2000s
- Jan 1, 2007
Earliest Phase 3 Sponsor(trial)
Indications
Approved for
Mechanism of action
- Unspecified targetOTHER
Unknown
Dequalinium chloride (DQC) has a broad spectrum against gram-positive and -negative bacteria, yeasts, and protozoa. The antimicrobial activity of DQC is primarily based on their ability to increase cell permeability with subsequent loss of enzyme activity. The mechanism of action of DQC is based on the following actions: Adsorption on the cell surface and diffusion through the cell wall disturbing the cell permeability. Denaturation of proteins and discontinuation of synthesis in ribosomes. Loss of enzymatic activity. Precipitation of nucleic acid. Its multiple mode of action is thought to reduce the risk of resistance of pathogens.
Chemistry & pharmacology
SMILES
Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]1c(C)cc(N)c2ccccc21- Mol. weight
- 456.68 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL333826 ↗
- ChEMBLCHEMBL121663 ↗
Also known as
- 1,1'-(1,10-decanediyl)bis(4-amino-2-methylquinolinium) dichloride
- 1,1'-(1,10-decanediyl)bis(4-amino-2-methylquinolinium) dichloride
- 1,1'-decamethylenebis(4-aminoquinaldinium chloride)
- 1,1'-decamethylenebis(4-aminoquinaldinium chloride)
- baqd 10
- baqd 10
- decamethylenebis(4-aminoquinaldinium chloride)
- decamethylenebis(4-aminoquinaldinium chloride)
- dequacets
- dequadin
- dequadin
- dequalinium
- dequalinium
- dequalinium
- dequalinium
- dequalinium
- dequalinium
- dequalinium
- dequalinium chloride
- dequalinium chloride
- dequalinium chloride
- dequalinium chloride
- dequalinium dichloride
- fluomizin
- gnf-pf-5483
- gnf-pf-5483
- labosept
- labosept
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT02242695 | Phase 4 | Nov 1, 2014 | Mahidol University, Medinova AG |
| NCT01125410 | Phase 3 | Jan 1, 2007 | Medinova AG |
Organizations
Research & Development (2)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Medinova AG | For profit | 2 | 2 | 2 | 2007 |
| Mahidol University | Academic/Hospital | 1 | 0 | 1 | 2014 |