cyclomandol
Cyclandelate is a vasodilator developed for the treatment of cardiovascular diseases. The drug was used in many countries for such diseases as intermittent claudication, arteriosclerosis obliterans, thrombophlebitis, nocturnal leg cramps, local frostbite, Raynaud's phenomenon. In the USA it was also approved for intermittent claudication and cognitive dysfunction in Alzheimer's disease under the name Cyclospasmol. Cyclandelate exerts its effect by blocking calcium channels and inhibiting smooth muscles contration. Cyclandelate was withdrawn from the market in the USA for lack of effectiveness. — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 0 marketing orgs
Indications
Approved for
Mechanism of action
- Unspecified targetOTHER
Unknown
Cyclandelate is a vasodilating agent that acts directly on the smooth muscles of blood vessels. It produces clinical effects in cerebral as well as peripheral vascular diseases. Cyclandelate inhibits the aggregation patterns of blood platelets stimulated with a variety of agonists such as adenosine diphosphate, thrombin, collagen, adrenaline (epinephrine) and platelet activating factor. It maintains red cell deformability by inhibiting calcium entry through the red cell membrane.
Chemistry & pharmacology
SMILES
CC1CC(CC(C)(C)C1)OC(=O)C(O)C2=CC=CC=C2- Mol. weight
- 276.3707 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Racemic Mixture
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaCyclandelate ↗
- NCATS4139O1OAY2 ↗
- ChEMBLCHEMBL1480987 ↗
Also known as
- 3,3,5-trimethylcyclohexyl mandelate
- 3,3,5-trimethylcyclohexyl mandelate
- 3,5,5-trimethylcyclohexyl amygdalate
- 3,5,5-trimethylcyclohexyl amygdalate
- ciclandelato
- ciclandelato
- cyclandelate
- cyclandelate
- cyclandelate
- cyclandelate
- cyclandelate
- cyclandelate
- cyclandelate
- cyclandelatum
- cyclandelatum
- cyclergine
- cyclobral
- cyclobral
- cyclobral
- cyclolyt
- cyclomandol
- cyclospasmol
- cyclospasmol