chlorcyclizine
Small moleculeexperimental
Chlorcyclizine is a first generation phenylpiperazine class antihistamine used to treat urticaria, rhinitis, pruritus, and other allergy symptoms. Chlorcyclizine also has some local anesthetic, anticholinergic, and antiserotonergic properties, and can be used as an antiemetic. Chlorcyclizine temporarily relieves the symptoms due to hay fever or other upper respiratory allergies. It has also being shown to possess in vitro and in vivo activity against hepatitis C virus. — NCATS
Clinical trial activity
1 trials · 1 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
0
Phase 3
0
Phase 4
0
Earliest trial started Mar 20, 2014 (NCT02118012)
Timeline
2010s
- Jan 1, 2014
Earliest Phase 1 Sponsor(trial)
Indications
Approved for
Studied for
Mechanism of action
- Histamine H1 receptorINHIBITOR
HRH1 inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
CN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1- Mol. weight
- 300.83 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Racemic Mixture
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL22150 ↗
- WikipediaChlorcyclizine ↗
- NCATSM26C4IP44P ↗
- ChEMBLCHEMBL1889091 ↗
Also known as
- chlorcycline
- chlorcycline
- chlorcyclizin
- chlorcyclizin
- chlorcyclizine
- chlorcyclizine
- chlorcyclizine
- chlorcyclizine
- chlorcyclizine
- chlorcyclizine
- chlorcyclizine
- chlorcyclizine
- chlorcyclizine
- chlorcyclizine hcl
- chlorcyclizine hcl
- chlorcyclizine hcl
- chlorcyclizine hydrochloride
- chlorcyclizine hydrochloride
- chlorcyclizine hydrochloride
- chlorcyclizinum
- chlorcyclizinum
- chlorocycline
- chlorocyclizin
- clorciclizina
- clorciclizina
- di-paralene
- di-paralene
- histachlorazine
- perazil
- perazil
- perazyl
- piperazine, 1-(((4-chlorophenyl)phenyl)methyl)-4-methyl-
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT02118012 | Phase 1 | Mar 20, 2014 | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
Showing 1 of 1 trials
Page 1 / 1
Organizations
Research & Development (1)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Government | 1 | 1 | 1 | 2014 |
1 organizations
Page 1 / 1