calcitonin, human
Trade name: cibacalcin
Small moleculeapproved
Approved
Oct 31, 1986
Calcitonin is a 32 amino acid peptide hormone secreted by parafollicular cells (also known as C cells) of the thyroid (or endostyle) in humans and other chordates in the ultimopharyngeal body. It acts to reduce blood calcium (Ca2+), opposing the effects of parathyroid hormone (PTH). — Wikipedia
Clinical trial activity
1 trials · 1 clinical orgs · 2 marketing orgs
Phase 1
0
Phase 2
1
Phase 3
0
Phase 4
0
Earliest trial started Jul 1, 2012 (NCT01623622)
Timeline
1970s
- Jun 21, 1977
Ciba-Geigy — First NDA Organization
- Jun 21, 1977
Ciba-Geigy — NDA Organization
1980s
2010s
- Jan 1, 2012
Earliest Phase 2 Sponsor(trial)
Indications
Approved for
Studied for
Mechanism of action
- Calcitonin receptorAGONIST
CALCR agonist
Approval history
- approvedPriority reviewOct 31, 1986
Chemistry & pharmacology
Loading structure…
SMILES
CNC(Cc1ccccc1)C(=O)C(C)C2CC(=O)NCCCC(CC(=C)C(Cc3c[nH]cn3)C(C)C(=O)C(Cc4ccccc4)CC(=O)C(CCCCN)C(C)C2=C)C(=O)C- Mol. weight
- 834.16 g/mol
- Lipinski Ro5
- 2 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Delivery
- Parenteral
- Availability
- Discontinued
Oral
No
Parenteral
Yes
Topical
No
Sources
- WikipediaCalcitonin ↗
- NCATSI0IO929019 ↗
- ChEMBLCHEMBL4594248 ↗
- ChEMBLCHEMBL359713 ↗
- ChEMBLCHEMBL1201614 ↗
Also known as
- calcitonin human
- calcitonin human
- calcitonin human
- calcitonin human
- calcitonin (human)
- calcitonin, human
- calcitonin, human
- calcitonin (human synthetic)
- calcitonin (human synthetic)
- calcitonin (human synthetic)
- calcitonin (human synthetic)
- calcitonin (human synthetic)
- calcitonin, human synthetic
- cibacalcin
- cibacalcin
- cibacalcin
- cibacalcin
- hc-58
- hc-58
- human calcitonin
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT01623622 | Phase 2 | Jul 1, 2012 | Asahi Kasei Pharma |
Showing 1 of 1 trials
Page 1 / 1
Organizations
Research & Development (1)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Asahi Kasei Pharma | For profit | 1 | 1 | 1 | 2012 |
1 organizations
Page 1 / 1
Marketing (3)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| Ciba-Geigy | For profit | NDA | Jun 21, 1977 |
| Novartis | For profit | MKTG | Oct 31, 1986 |
| Novartis | For profit | NDA2 | Oct 31, 1986 |