bentiromide
Trade name: chymex
Approved
Dec 29, 1983
Bentiromide (Chymex) is a diagnostic agent that was approved for the diagnosis of pancreatic exocrine insufficiency. It is given by mouth as a noninvasive test. The amount of p-aminobenzoic acid and its metabolites excreted in the urine is taken as a measure of the chymotrypsin-secreting activity of the pancreas. Headache and gastrointestinal disturbances have been reported in patients taking bentiromide. Bentiromide is not available in the United States or Canada. — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 2 marketing orgs
Timeline
1980s
- Jun 1, 1983
Warren Teed — First NDA Organization
- Jun 1, 1983
Warren Teed — NDA Organization
- Dec 29, 1983
Earliest FDA Approval
- Dec 29, 1983
Savage Labs — Marketing Organization
- Dec 29, 1983
Savage Labs — NDA Secondary Org
Indications
Mechanism of action
- Alpha-chymotrypsinSUBSTRATE
Alpha-chymotrypsin substrate
Approval history
- approvedDec 29, 1983
Chemistry & pharmacology
SMILES
OC(=O)C1=CC=C(NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)C3=CC=CC=C3)C=C1- Mol. weight
- 404.4153 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral
- Availability
- Discontinued
Oral
Yes
Parenteral
No
Topical
No
Sources
- WikipediaBentiromide ↗
- NCATS239IF5W61J ↗
- ChEMBLCHEMBL1200368 ↗
Also known as
- bentiromide
- bentiromide
- bentiromide
- bentiromide
- bentiromide
- bentiromide
- bentiromide
- bentiromide
- bentiromide
- bentiromido
- bentiromido
- bentiromidum
- bentiromidum
- benzoyl-tyrosyl-paba
- btpaba
- btpaba
- btpaba pft
- btpaba pft
- chymex
- chymex
- chymex
- e-2663
- e-2663
- n-benzoyl-l-tyrosyl-paba
- n-benzoyl-l-tyrosyl-p-aminobenzoic acid
- paba-peptide
- pft
- pft
Organizations
Marketing (3)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| Savage Labs | For profit | MKTG | Dec 29, 1983 |
| Savage Labs | For profit | NDA2 | Dec 29, 1983 |
| Warren Teed | For profit | NDA | Jun 1, 1983 |