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tolrestat

Small moleculeexperimental

Tolrestat is an aldose reductase inhibitor which was approved for the control of certain diabetic complications. — Wikipedia

Clinical trial activity

0 trials · 0 clinical orgs · 0 marketing orgs

Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0

Mechanism of action

  • Aldose reductaseINHIBITOR

    AKR1B1 inhibitor

    It reduces the flux of glucose through the polyol pathway, inhibiting tissue accumulation of sorbitol and fructose and preventing reduction of redox potentials.

    Tolrestat inhibited in dose-dependent fashion the aldose reductase from bovine lenses (IC50, 3.5 X 10(-8) mol/L) and the formation of sorbitol in human red blood cells incubated with glucose (IC50, 3 X 10(-8) mol/L)

    PDBe: 2fzd

Chemistry & pharmacology

Loading structure…

SMILES

COc1ccc2c(C(=S)N(C)CC(=O)O)cccc2c1C(F)(F)F
Mol. weight
357.35 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Achiral Molecule
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • alderase
  • alredase
  • alredase
  • alredase
  • ay 27773
  • ay-27773
  • ay-27773
  • ay-27773
  • ay-27,773
  • lorestat
  • n-((5-(trifluoromethyl)-6-methoxy-1-naphthalenyl)thioxomethyl)-n-methylglycine
  • n-5-trifluoromethyl-6-methoxy-1-thionaphthoyl-n-methylglycine
  • tolrestat
  • tolrestat
  • tolrestat
  • tolrestat
  • tolrestat
  • tolrestat
  • tolrestat
  • tolrestat
  • tolrestatin