almitrine
Almitrine is a diphenylmethylpiperazine derivative classified as a respiratory stimulant by the ATC. It enhances respiration by acting as an agonist of peripheral chemoreceptors located on the carotid bodies. The drug increases arterial oxygen tension while decreasing arterial carbon dioxide tension in patients with chronic obstructive pulmonary disease. It may also prove useful in the treatment of nocturnal oxygen desaturation without impairing the quality of sleep. A significant literature exists for this compound, including over 60 papers that Medline labels as reviews. — Wikipedia
Clinical trial activity
1 trials · 2 clinical orgs · 0 marketing orgs
Earliest trial started May 31, 2020 (NCT04357457)
Timeline
2020s
- Jan 1, 2020
Earliest Phase 3 Sponsor(trial)
Indications
Mechanism of action
- Unspecified targetOTHER
Unknown
Almitrine is a respiratory stimulant that enhances respiration by acting as an agonist of peripheral chemoreceptors located on the carotid bodies. The drug increases arterial oxygen tension while decreasing arterial carbon dioxide tension in patients with chronic obstructive pulmonary disease. It may also prove useful in the treatment of nocturnal oxygen desaturation without impairing the quality of sleep.
Chemistry & pharmacology
SMILES
C=CCNc1nc(NCC=C)nc(N2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)n1- Mol. weight
- 477.56 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaAlmitrine ↗
- ChEMBLCHEMBL314610 ↗
- ChEMBLCHEMBL1183717 ↗
Also known as
- 2,4-bis(allylamino)-6-(4-(bis(p-fluorophenyl)methyl)-1-piperazinyl)-s-triazine
- 2,4-bis(allylamino)-6-(4-(bis(p-fluorophenyl)methyl)-1-piperazinyl)-s-triazine
- almitrina
- almitrina
- almitrine
- almitrine
- almitrine
- almitrine
- almitrine
- almitrine
- almitrine
- almitrine
- almitrine dimesilate
- almitrine mesilate
- almitrinum
- almitrinum
- duxil
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT04357457 | Phase 3 | May 31, 2020 | Assistance Publique - Hôpitaux de Paris, Centre Hospitalier of Chartres |
Organizations
Research & Development (2)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Assistance Publique - Hôpitaux de Paris | Academic/Hospital | 1 | 1 | 1 | 2020 |
| Centre Hospitalier of Chartres | Academic/Hospital | 1 | 0 | 1 | 2020 |