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sivifene

Small moleculeexperimental

Sivifene is a small-molecule antineoplastic agent and immunomodulator that was under development in the 2000s by Tigris Pharmaceuticals as a topical treatment for cutaneous cancer metastases. It was specifically being investigated to treat high-grade squamous intraepithelial lesions (HSIL) associated with human papillomavirus (HPV) infection and invasive carcinomas of the anogenital area such as cervical, vaginal, and anal cancers. The drug reached phase II clinical trials prior to its discontinuation. — Wikipedia

Clinical trial activity

3 trials · 28 clinical orgs · 0 marketing orgs

Phase 1
1
Phase 2
2
Phase 3
0
Phase 4
0

Earliest trial started Nov 2, 1999 (NCT00002153)

Timeline

1990s

  1. Jan 1, 1999

    Earliest Phase 1 Sponsor(trial)

2000s

  1. Jan 1, 2006

    Earliest Phase 2 Sponsor(trial)

Indications

Studied for

Mechanism of action

  • Unspecified targetUnclear

    unclear

Chemistry & pharmacology

Loading structure…

SMILES

O=[N+]([O-])c1ccc(NN=C(c2ccc(O)cc2)c2ccc(O)cc2)c([N+](=O)[O-])c1
Mol. weight
394.34 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Achiral Molecule
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • 4,4'-dihydroxybenzophenone-2,4-dinitrophenylhydrazone
  • 4,4'-dihydroxybenzophenone-2,4-dinitrophenylhydrazone
  • 4,4'-dihydroxybenzophenone-2,4-dinitrophenylhydrazone
  • a007
  • a007
  • a 007
  • a-007
  • a-007
  • a-007
  • sivifene
  • sivifene

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT00596258Phase 2Nov 1, 2007Kirax, New York University, Robin Black OGNP, Costa Mesa California, Visions Clinical Research, Yeshiva University
NCT00285207Phase 2Jan 1, 2006Augusta University, Coastal Connecticut Research, LLC, Georgetown University, Global OB/GYN Centers of Florida, Greater Cincinnati OB/GYN, Inc., Hill Country OB/GYN, Hope Research Institute, LLC, IGO Medical Group of San Diego, Jersey Shore University Medical Center, Kirax, Mount Vernon Clinical Research, LLC, New York Presbyterian Hospital, Northern California Research Corp, OB/GYN Specialists of the Palm Beaches, Office of R. Garn Mabey, MD, Physician Care Clinical Research LLC, Planned Parenthood, Robin Black OGNP, Costa Mesa California, South Carolina Oncology Associates, University of Alabama, University of California, Irvine, University of Oklahoma, University of Pittsburgh, University of South Florida, Visions Clinical Research, Yeshiva University
NCT00002153Phase 1Nov 2, 1999DEKK-TEC, Inc.
Showing 3 of 3 trials
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Organizations

Research & Development (28)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
KiraxFor profit2212006
Robin Black OGNP, Costa Mesa CaliforniaAcademic/Hospital2012006
Visions Clinical ResearchFor profit2012006
Yeshiva UniversityAcademic/Hospital2012006
Augusta UniversityAcademic/Hospital1012006
Coastal Connecticut Research, LLCFor profit1012006
DEKK-TEC, Inc.For profit1111999
Georgetown UniversityAcademic/Hospital1012006
Global OB/GYN Centers of FloridaAcademic/Hospital1012006
Greater Cincinnati OB/GYN, Inc.Academic/Hospital1012006
Hill Country OB/GYNAcademic/Hospital1012006
Hope Research Institute, LLCFor profit1012006
IGO Medical Group of San DiegoAcademic/Hospital1012006
Jersey Shore University Medical CenterAcademic/Hospital1012006
Mount Vernon Clinical Research, LLCFor profit1012006
New York Presbyterian HospitalAcademic/Hospital1012006
New York UniversityAcademic/Hospital1012007
Northern California Research CorpFor profit1012006
OB/GYN Specialists of the Palm BeachesAcademic/Hospital1012006
Office of R. Garn Mabey, MDAcademic/Hospital1012006
28 organizations
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