troleandomycin
Trade name: tao
Approved
May 27, 1969
Troleandomycin (also known Triacetyl-oleandomycin and having brand name Tao) is a macrolide antibiotic which used to for the treat of infections of the upper and lower respiratory tract: such as tonsillitis, bronchitis, sinusitis, and pneumonia. However, the brand name Tao was discontinued. Troleandomycin acts by penetrating the bacterial cell membrane and reversibly binding to the 50 S subunit of bacterial ribosomes or near the "P" or donor site so that binding of tRNA (transfer RNA) to the donor site is blocked. Translocation of peptides from the "A" or acceptor site to the "P" or donor site is prevented, and subsequent protein synthesis is inhibited. — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 1 marketing orgs
Timeline
Indications
Approved for
Mechanism of action
- 50S ribosomal protein L2ANTAGONIST
rplB antagonist
Approval history
- approvedMay 27, 1969
Chemistry & pharmacology
SMILES
CO[C@H]1C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3OC(C)=O)N(C)C)[C@@H](C)C[C@@]4(CO4)C(=O)[C@H](C)[C@@H](OC(C)=O)[C@@H](C)[C@@H](C)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1OC(C)=O- Mol. weight
- 813.9684 g/mol
- Lipinski Ro5
- 2 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral
- Availability
- Discontinued
Oral
Yes
Parenteral
No
Topical
No
Sources
- WikipediaTroleandomycin ↗
- NCATSC4DZ64560D ↗
- ChEMBLCHEMBL564085 ↗
Also known as
- acetyloleandomycin
- acetyloleandomycin
- cyclamycin
- evramicina
- evramycin
- oleandomycin triacetate
- oleomycin
- tao
- tao
- tao
- triacetyloleandomycin
- triacetyloleandomycin
- triacetyloleandomycin
- troleandomycin
- troleandomycin
- troleandomycin
- troleandomycin
- troleandomycin
- troleandomycin
- troleandomycin
- troleandomycin
- troleandomycin