sulfamethizole

Trade name: thiosulfil

Small moleculeapproved

Approved

Oct 28, 1953

Sulfamethizole is an oral antiobiotic, which was used against urinary tract infections under the name Thiosulfil. Sulfamethizole blocks bacterial growth by inhibiting folic acid synthesis via enzyme called dihydropteroate synthase. The drug is no longer marketed in the USA. — NCATS

Clinical trial activity

0 trials · 0 clinical orgs · 3 marketing orgs

Phase 1

Phase 2

Phase 3

Phase 4

Timeline

1950s

Oct 28, 1953
Wyeth — Earliest FDA Approval
Oct 28, 1953
American Home Products — NDA Secondary Org
Oct 28, 1953
Wyeth — NDA Organization

Indications

Approved for

Urinary Tract Infections (approved 1953)

Mechanism of action

Bacterial dihydropteroate synthaseINHIBITOR
folP inhibitor
Broad spectrum
- Dihydropteroate synthase (folP) ↗

Approval history

approvedOct 28, 1953

Chemistry & pharmacology

Loading structure…

SMILES

CC1=NN=C(NS(=O)(=O)C2=CC=C(N)C=C2)S1

Mol. weight: 270.331 g/mol
Lipinski Ro5: Pass
Rule of 3: No
Chirality: Achiral Molecule
Inorganic: No
Polymer: No
Delivery: Oral
Availability: Discontinued

Oral

Yes

Parenteral

Topical

Sources

Also known as

methazol
methazol
microsul
microsul
proklar
proklar
rufol
rufol
sulfamethiazole
sulfamethizol
sulfamethizol
sulfamethizol
sulfaméthizol
sulfaméthizol
sulfamethizole
sulfamethizole
sulfamethizole
sulfamethizole
sulfamethizole
sulfamethizole
sulfamethizole
sulfamethizole
sulfamethizole
sulfamethizole
sulfamethizole
sulfamethizolum
sulfamethizolum
sulfamethylthiadiazole
sulfamethylthiadiazole
sulfamethylthiadiazole
sulfametizol
sulfametizol
sulfurine
sulphamethizole
sulphamethizole
sulphamethizole
sulphamethylthiadiazole
tetracid
tetracid
thiosulfil
thiosulfil
thiosulfil
urolucosil
urolucosil

Organizations

Marketing (3)

Organization	Org type	Relationship	Date
American Home Products	For profit	NDA2	Oct 28, 1953
Forest Laboratories	For profit	MKTG	—
Wyeth	For profit	NDA	Oct 28, 1953