propiomazine

Trade name: largon

Small moleculeapproved

Approved

Dec 5, 1960

Propiomazine is a typical antipsychotic, blocking H1 receptors and is primarily indicated in conditions Insomnia. Propiomazine was also used under brand name largon for the relief of restlessness and apprehension, preoperatively or during surgery. In addition largon was used as an adjunct to analgesics for the relief of restlessness and apprehension during labor. But this drug was discontinued. — NCATS

Clinical trial activity

0 trials · 0 clinical orgs · 2 marketing orgs

Phase 1

Phase 2

Phase 3

Phase 4

Timeline

1960s

Dec 5, 1960
West-Ward Pharmaceutical — Earliest FDA Approval
Dec 5, 1960
West-Ward Pharmaceutical — NDA Organization
Dec 5, 1960
West-Ward Pharmaceutical — NDA Secondary Org
Dec 5, 1960
Hikma — Marketing Organization
Dec 5, 1960
Hikma — NDA Secondary Org

Indications

Approved for

Studied for

Sleep Initiation and Maintenance Disorders · Phase 4

Mechanism of action

Histamine H1 receptorANTAGONIST
HRH1 antagonist
- Histamine H1 receptor (HRH1) ↗

Approval history

approvedDec 5, 1960

Chemistry & pharmacology

Loading structure…

SMILES

CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2

Mol. weight: 340.49 g/mol
Lipinski Ro5: Pass
Rule of 3: No
Chirality: Racemic Mixture
Inorganic: No
Polymer: No
Delivery: Parenteral
Availability: Discontinued

Oral

Parenteral

Yes

Topical

Sources

Also known as

10-(2-dimethylaminopropyl)-2-propionylphenothiazine
10-(2-dimethylaminopropyl)-2-propionylphenothiazine
1-propanone, 1-(10-(2-(dimethylamino)propyl)-10h-phenothiazin-2-yl)-
2-propionyl-10-(2-(dimethylamino)propyl)phenothiazine
2-propionyl-10-(2-(dimethylamino)propyl)phenothiazine
3-propionyl-10-dimethylaminoisopropylphenothiazine
3-propionyl-10-dimethylaminoisopropylphenothiazine
cb-1678
cb-1678
dorevan
dorevan
dorevane
dorevane
indorm
indorm
largon
largon
largon
largon
largon
largon
largon
propavan
propavan
propiomazin
propiomazin
propiomazina
propiomazina
propiomazine
propiomazine
propiomazine
propiomazine
propiomazine
propiomazine
propiomazine
propiomazine
propiomazine
propiomazine hcl
propiomazine hcl
propiomazine hcl
propiomazine hydrochloride
propiomazine hydrochloride
propiomazine hydrochloride
propiomazine hydrochloride
propiomazinum
propiomazinum
propionylpromethazine
wy-1359
wy-1359

Organizations

Marketing (4)

Organization	Org type	Relationship	Date
Hikma	For profit	MKTG	Dec 5, 1960
Hikma	For profit	NDA2	Dec 5, 1960
West-Ward Pharmaceutical	For profit	NDA	Dec 5, 1960
West-Ward Pharmaceutical	For profit	NDA2	Dec 5, 1960