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nikethamide

Trade name: coramine

Small moleculemarketed

Approved

Jul 1, 1922

Nikethamide is a stimulant which mainly affects the respiratory cycle. Widely known by its former trade name of Coramine, it was used in the mid-twentieth century as a medical countermeasure against tranquilizer overdoses, before the advent of endotracheal intubation and positive-pressure lung expansion. It is no longer commonly considered to be of value for such purposes. — Wikipedia

Clinical trial activity

0 trials · 0 clinical orgs · 0 marketing orgs

Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0

Timeline

1920s

  1. Jul 1, 1922

    Evidence of US Marketing

Indications

Approved for

Mechanism of action

  • Unspecified targetOTHER

    Unknown

    Whether it increases the sensitivity of the respiratory centre to CO2 levels, acts on the chemoreceptors of the carotid body, or simply wakens the patient to enable him to co-operate with coughing is not clear.

Approval history

  • approvedJul 1, 1922

Chemistry & pharmacology

Loading structure…

SMILES

CCN(CC)C(=O)c1cccnc1
Mol. weight
178.24 g/mol
Lipinski Ro5
Pass
Rule of 3
Yes
Chirality
Achiral Molecule
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • anacardone
  • anacordone
  • carbamidal
  • coramine
  • coramine
  • niamine
  • nicamide
  • nicetamide
  • nicethamide
  • nicethamide
  • nicethamide
  • nicorine
  • nicotinic acid diethylamide
  • nicotinic acid diethylamide
  • nicotinic acid diethylamide
  • nikethamide
  • nikethamide
  • nikethamide
  • nikethamide
  • nikethamide
  • nikethamide
  • nikethamide
  • nikethamide
  • nikethyl
  • nikethyl
  • pyricardyl