mequinol
Trade name: Solage
Small moleculeapproved
Approved
Dec 10, 1999
Mequinol (mequinol is 4-hydroxyanisole) is an active ingredient in topical drugs used for skin depigmentation. The mechanism of action of mequinol is unknown. Although mequinol is a substrate for the enzyme tyrosinase and acts as a competitive inhibitor of the formation of melanin precursors, the clinical significance of these findings is unknown. — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 2 marketing orgs
Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0
Timeline
1990s
- Dec 10, 1999
Earliest FDA Approval
- Dec 10, 1999
Almirall — NDA Secondary Org
Indications
Approved for
Mechanism of action
- TyrosinaseINHIBITOR
TYR inhibitor
Combination products
solage
with tretinoin
Approval history
- approvedDec 10, 1999
Chemistry & pharmacology
Loading structure…
SMILES
COC1=CC=C(O)C=C1- Mol. weight
- 124.1372 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Racemic Mixture
- Inorganic
- No
- Polymer
- No
- Availability
- Discontinued
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaMequinol ↗
- NCATS6HT8U7K3AM ↗
- ChEMBLCHEMBL544 ↗
- ChEMBLCHEMBL1597075 ↗
Also known as
- 2-aminobenzoate
- 2-aminobenzoate
- 2-aminobenzoate
- 2-aminobenzoate
- 4ha
- 4-hydroxyanisole
- 4-hydroxyanisole
- 4-hydroxyanisole
- 4-hydroxyanisole, potassium salt
- 4-hydroxyanisole, sodium salt
- 4-methoxyphenol
- 4-methoxyphenol
- 4-methoxyphenol
- 4-methoxyphenol
- bms-181158
- bms-181158
- hqmme; hydroxyquinone methyl ether
- hqmme; hydroxyquinone methyl ether
- hydroquinone methyl ether
- hydroquinone methyl ether
- hydroquinone monomethyl ether
- leucobasal
- leucobasal
- leucodine b
- leucodine b
- leucodinine b
- mechinolum
- mechinolum
- menthyl anthranilate
- menthyl anthranilate
- menthyl anthranilate
- mequinol
- mequinol
- mequinol
- mequinol
- mequinol
- mequinol
- mequinol
- mequinol
- meradimate
- novo-dermoquinona
- novo-dermoquinona
- para-methoxyphenol
- p-guaiacol
- p-guaiacol
- p-hydroxyanisol
- p-hydroxyanisole
- p-hydroxyanisole
- p-hydroxyanisole
- p-hydroxymethoxybenzene