isoflurophate
Trade name: floropryl
Small moleculeapproved
Approved
Apr 2, 1957
Isofluorophate (diisopropyl fluorophosphate) is an irreversile acetylcholinesterase inhibitor. It was used in ophthalmology as a miotic agent in treatment of chronic glaucoma. — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 1 marketing orgs
Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0
Timeline
Indications
Approved for
Mechanism of action
- AcetylcholinesteraseINHIBITOR
ACHE inhibitor
Approval history
- approvedApr 2, 1957
Chemistry & pharmacology
Loading structure…
SMILES
CC(C)OP(F)(=O)OC(C)C- Mol. weight
- 184.1457 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
- Delivery
- Topical
- Availability
- Discontinued
Oral
No
Parenteral
No
Topical
Yes
Sources
- WikipediaDiisopropyl fluorophosphate ↗
- NCATS12UHW9R67N ↗
- ChEMBLCHEMBL1025 ↗
Also known as
- dfp
- dfp
- difluorophate
- diflupyl
- diisopropoxyphosphoryl fluoride
- diisopropoxyphosphoryl fluoride
- diisopropylfluorophosphate
- diisopropylfluorophosphate
- diisopropyl fluorophosphate
- diisopropyl fluorophosphate
- diisopropyl fluorophosphate
- diisopropyl fluorophosphonate
- diisopropyl fluorophosphonate
- diisopropylfluorophosphoric acid ester
- diisopropylfluorophosphoric acid ester
- diisopropylphosphofluoridate
- diisopropylphosphofluoridate
- diisopropyl phosphofluoridate
- diisopropyl phosphofluoridate
- diisopropylphosphorofluoridate
- diisopropylphosphorofluoridate
- diisopropyl phosphorofluoridate
- diisopropyl phosphorofluoridate
- dyflos
- dyflos
- floropryl
- floropryl
- floropryl
- fluorodiisopropyl phosphate
- fluorodiisopropyl phosphate
- fluorostigmine
- fluorostigmine
- fluostigmine
- fluostigmine
- fluostigmine
- fluostigmine
- isofluorphate
- isofluorphate
- isoflurophate
- isoflurophate
- isoflurophate
- isoflurophate
- isoflurophate
- isoflurophate
- isoflurophate
- isoflurophate
- isoflurophate
- isoflurophosphate
- isoflurophosphate
- isopropyl fluophosphate
- isopropyl fluophosphate
- isopropyl phosphorofluoridate
- isopropyl phosphorofluoridate
- neoglaucit
- neoglaucit
- o,o'-diisopropyl phosphoryl fluoride
- o,o'-diisopropyl phosphoryl fluoride
- phosphorofluoridic acid
Organizations
Marketing (1)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| Merck | For profit | NDA | Apr 2, 1957 |