iothalamate sodium i-125
Trade name: GloFil
Approved
Aug 16, 1962
Iothalamic acid is a Radiographic Contrast Agent. The mechanism of action of iothalamic acid is as a X-Ray Contrast Activity. GLOFIL-125 (Sodium Iothalamate I-125 Injection) is a sterile, nonpyrogenic aqueous injection containing approximately 1 mg sodium iothalamate per mL, and 0.9 percent benzyl alcohol as a preservative. The radioactive concentration of the material is 250-300 µCi/mL as of the calibration date. Sodium bicarbonate and hydrochloric acid are present for pH adjustment. GLOFIL-125 (Sodium Iothalamate I-125 Injection) is indicated for evaluation of glomerular filtration in the diagnosis or monitoring of patients with renal disease. The renal clearance of sodium iothalamate in man closely approximates that of inulin. The compound is cleared by glomerular filtration without tubular secretion or reabsorption. Following infusion administration of I-125 iothalamate, the effective half-life is about 0.07 days. — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 4 marketing orgs
Timeline
1960s
- Aug 16, 1962
Liebel-Flarsheim — Earliest FDA Approval
- Aug 16, 1962
Liebel-Flarsheim — NDA Secondary Org
- Aug 16, 1962
Liebel-Flarsheim — NDA Organization
- Sep 30, 1963
Mallinckrodt — NDA Secondary Org
1970s
- Feb 12, 1974
IsoTex — NDA Secondary Org
1990s
- Apr 26, 1996
International Minerals and Chemical Corporation — NDA Secondary Org
Indications
Approved for
Mechanism of action
- Unspecified targetOTHER
Diagnostic agent
- contrast mediumRadiopaque
contrast medium radiopaque
Approval history
- approvedPriority reviewAug 16, 1962
Chemistry & pharmacology
SMILES
CNC(=O)C1=C([125I])C(C(O)=O)=C([125I])C(NC(C)=O)=C1[125I]- Mol. weight
- 607.914 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
- Delivery
- Parenteral
- Availability
- Discontinued
- Payload
- 125-iodine
Oral
No
Parenteral
Yes
Topical
No
Sources
- NCATS2XLB86RCW8 ↗
- ChEMBLCHEMBL2106318 ↗
- ChEMBLCHEMBL1201125 ↗
- ChEMBLCHEMBL1097620 ↗
Also known as
- angio-conray
- angio-conray
- conray
- conray
- conray
- conray 30
- conray 30
- conray 325
- conray 325
- conray 400
- conray 400
- conray 43
- conray 43
- cysto-conray ii
- glofil-125
- glofil-125
- glofil-125
- iothalamate
- iothalamate
- iothalamate meglumine
- iothalamate meglumine
- iothalamate meglumine
- iothalamate meglumine
- iothalamate sodium
- iothalamate sodium
- iothalamate sodium
- iothalamate sodium
- iothalamate sodium (125i)
- iothalamate sodium (125i)
- iothalamate sodium i 125
- iothalamate sodium i 125
- iothalamate sodium i-125
- iothalamate sodium i-125
- iothalamate sodium i-125
- meglumine iotalamate injection
- meglumine iotalamate injection
- sodium iotalamate (125i)
- sodium iotalamate (125i)
- sodium iotalamate injection
- sodium iotalamate injection
- sodium iothalamate
- sodium iothalamate
- sodium iothalamate (125i)
- sodium iothalamate (125i)
Organizations
Marketing (5)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| International Minerals and Chemical Corporation | For profit | NDA2 | Apr 26, 1996 |
| IsoTex | For profit | NDA2 | Feb 12, 1974 |
| Liebel-Flarsheim | For profit | NDA2 | Aug 16, 1962 |
| Liebel-Flarsheim | For profit | NDA | Aug 16, 1962 |
| Mallinckrodt | For profit | NDA2 | Sep 30, 1963 |