gallamine
Trade name: flaxedil
Small moleculeapproved
Gallamine triethiodide is a synthetic nondepolarizing blocking drug, which is allosteric antagonist of muscarinic M2 acetylcholine receptor and inhibitor of acetylcholinesterase. It was used under brand name flaxedil to stabilize muscle contractions during surgical procedures. However, this usage was discontinued. It was shown, that gallamine caused tachycardia by depressing the vagus nerve and, occasionally, hypertension and increased cardiac output. — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 1 marketing orgs
Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0
Timeline
1950s
- Apr 25, 1950
Davis & Geck — First NDA Organization
- Apr 25, 1950
Davis & Geck — NDA Organization
Indications
Approved for
Mechanism of action
Muscle-type nicotinic acetylcholine receptor antagonist
non-depolarizing
Approval history
- approved—
Chemistry & pharmacology
Loading structure…
SMILES
CC[N+](CC)(CC)CCOc1cccc(OCC[N+](CC)(CC)CC)c1OCC[N+](CC)(CC)CC- Mol. weight
- 510.83 g/mol
- Lipinski Ro5
- 2 violation(s)
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
- Delivery
- Parenteral
- Availability
- Discontinued
Oral
No
Parenteral
Yes
Topical
No
Sources
- ChEMBLCHEMBL360055 ↗
- WikipediaGallamine triethiodide ↗
- NCATSVYJ027LZ05 ↗
- ChEMBLCHEMBL1200993 ↗
Also known as
- benzcurine iodide
- benzcurine iodide
- flaxedil
- flaxedil
- flaxedil
- flaxedil
- flaxedil
- flaxedil
- flaxedil
- gallamine
- gallamine
- gallamine
- gallamine
- gallamine
- gallamine triethiodide
- gallamine triethiodide
- gallamine triethiodide
- gallamine triethiodide
- gallamine triethiodide
- gallamine triethiodide
- gallamine triethochloride
- gallamine triethyl iodide
- gallamini triethiodidum
- gallamini triethiodidum
- gallamin triethiodid
- gallamin triethiodid
- gallamone triethiodide
- gallamone triethiodide
- gallamonium iodide
- gallomone triethiodide
- relaxan
- relaxan
- triéthiodure de gallamine
- triéthiodure de gallamine
- trietioduro de galamina
- trietioduro de galamina
Organizations
Marketing (1)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| Davis & Geck | For profit | NDA | Apr 25, 1950 |