crotamiton
Approved
Jul 6, 1949
Crotamiton (N-ethyl-N-(2-methylphenyl) but-2-enamide) is a scabicidal and antipruritic agent available as a cream or lotion for topical use only. Crotamiton is a mixture of the cis (Z) and trans (E) isomers. Crotamiton contains not less than 96.0 per cent and not more than the equivalent of 102.0 per cent of N-ethyl-N-(2-methylphenyl)but-2-enamide, calculated as the sum of the E- and Z-isomers, and not more than 15.0 per cent of the Z-isomer. Isomer-specific pharmacological activity of crotamiton is unknown. — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 5 marketing orgs
Timeline
1940s
- Jul 6, 1949
Earliest FDA Approval
- Jul 6, 1949
Sun Pharmaceuticals — NDA Secondary Org
- Jul 6, 1949
Fortress Biotech — Marketing Organization
- Jul 6, 1949
Fortress Biotech — NDA Secondary Org
1980s
- Dec 16, 1981
Marnel Pharmaceuticals — Marketing Organization
- Dec 16, 1981
LEGACY PHARMA — Marketing Organization
Indications
Approved for
Mechanism of action
- Unspecified targetOTHER
Unknown
Approval history
- approvedJul 6, 1949
Chemistry & pharmacology
SMILES
C/C=C/C(=O)N(CC)c1ccccc1C- Mol. weight
- 203.28 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- Yes
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
- Delivery
- Topical
- Availability
- Prescription Only
Oral
No
Parenteral
No
Topical
Yes
Sources
- WikipediaCrotamiton ↗
- NCATSD6S4O4XD0H ↗
- ChEMBLCHEMBL6067975 ↗
- ChEMBLCHEMBL1200709 ↗
Also known as
- crotalgin
- crotamitex
- crotamiton
- crotamiton
- crotamiton
- crotamiton
- crotamiton
- crotamiton
- crotamiton
- crotamiton
- crotamiton
- crotamiton
- crotamitone
- crotan
- crotan
- eurax
- eurax
- eurax
- eurax
- n-crotonyl-n-ethyl-o-toluidine
- n-ethyl-o-crotonotoluidide
- veteusan
Organizations
Marketing (6)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| Fortress Biotech | For profit | MKTG | Jul 6, 1949 |
| Fortress Biotech | For profit | NDA2 | Jul 6, 1949 |
| LEGACY PHARMA | For profit | MKTG | Dec 16, 1981 |
| Marnel Pharmaceuticals | For profit | MKTG | Dec 16, 1981 |
| Squibb | For profit | NDA | — |
| Sun Pharmaceuticals | For profit | NDA2 | Jul 6, 1949 |