ceruletide

Trade name: tymtran

Biologicalapproved

CERULETIDE, also known as caerulein, is a specific decapeptide obtained from the skin of Hila caerulea, an Australian amphibian. It is similar in action and composition to the natural gastrointestinal peptide hormone cholecystokinin. It stimulates gastric, biliary, and pancreatic secretion; and certain smooth muscle. In the research setting, CERULETIDE can be used to induce pancreatitis in experimental animal models. — NCATS

Clinical trial activity

0 trials · 0 clinical orgs · 2 marketing orgs

Phase 1

Phase 2

Phase 3

Phase 4

Timeline

1970s

Jul 18, 1978
Farmitalia Carlo Erba — First NDA Organization
Jul 18, 1978
Farmitalia Carlo Erba — NDA Organization

Indications

Approved for

Gastrointestinal Hormones (approved 1981)

Mechanism of action

Cholecystokinin A receptorAGONIST
CCKAR agonist
- Cholecystokinin receptor type A (CCKAR) ↗

Approval history

approved—

Chemistry & pharmacology

Loading structure…

SMILES

CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O

Mol. weight: 1352.43 g/mol
Chirality: Single Stereoisomer
Inorganic: No
Polymer: No
Delivery: Parenteral
Availability: Discontinued

Oral

Parenteral

Yes

Topical

Sources

Also known as

caerulein
caerulein
caerulein
caerulein compd. with n-ethylethanamine
caerulein diethylamine
caerulein diethylamine salt
cerulein
cerulein
ceruletida
ceruletida
ceruletide
ceruletide
ceruletide
ceruletide
ceruletide
ceruletide
ceruletide
ceruletide diethylamine
ceruletide diethylamine
ceruletide diethylamine
ceruletide diethylamine
ceruletide diethylamine
ceruletide diethylamine
ceruletide diethylamine
ceruletidum
ceruletidum
tymtran
tymtran
tymtran

Organizations

Marketing (2)

Organization	Org type	Relationship	Date
Farmitalia Carlo Erba	For profit	NDA	Jul 18, 1978
Pharmacia & Upjohn	For profit	NDA2	—