benzthiazide
Trade name: fovane
Approved
Jun 1, 1960
Benzthiazide (trade names Aquatag, Dihydrex, Diucen, Edemax, Exna, Foven and others) is a thiazide diuretic used in the treatment of high blood pressure and edema. It is no longer available in the United States. As a diuretic, benzthiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. The following is a list of possible side effects that may occur from all constituting ingredients of Exna Tablet: vomiting, diarrhoea, photosensitivity reactions, increased in uric acid concentrations, megaloblastic anaemia, thrombocytopenia. Exna tablet may interact with the following drugs and products: ACE inhibitors, angiotensin II receptor antagonists, potassium-sparing diuretics. — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 4 marketing orgs
Timeline
Indications
Mechanism of action
SLC12A3 inhibitor
Approval history
- approvedJun 1, 1960
Chemistry & pharmacology
SMILES
NS(=O)(=O)C1=C(Cl)C=C2N=C(CSCC3=CC=CC=C3)NS(=O)(=O)C2=C1- Mol. weight
- 431.937 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral
- Availability
- Discontinued
Oral
Yes
Parenteral
No
Topical
No
Sources
- WikipediaBenzthiazide ↗
- NCATS1TD8J48L61 ↗
- ChEMBLCHEMBL1532 ↗
- ChEMBLCHEMBL1201039 ↗
Also known as
- 3-benzylthiomethyl-6-chloro-2h-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
- 3-benzylthiomethyl-6-chloro-2h-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
- 3-benzylthiomethyl-6-chloro-7-sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide
- 3-benzylthiomethyl-6-chloro-7-sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide
- 3-((benzylthio)methyl)-6-chloro-7-sulfamoyl-2h-benzo-1,2,4-thiadiazine 1,1-dioxide
- 3-((benzylthio)methyl)-6-chloro-7-sulfamoyl-2h-benzo-1,2,4-thiadiazine 1,1-dioxide
- 3-((benzylthio)methyl)-6-chloro-7-sulfamoyl-2h-benzo-1,2,4-thiadiazine-1,1-dioxide
- 6-chloro-1,1-dioxo-3-(phenylmethylsulfanylmethyl)-4h-benzo[e][1,2,4]thiadiazine-7-sulfonamide
- 6-chloro-1,1-dioxo-3-(phenylmethylsulfanylmethyl)-4h-benzo[e][1,2,4]thiadiazine-7-sulfonamide
- 6-chloro-7-sulfamoyl-3-benzylthiomethyl-2h-1,2,4-benzothiadiazine 1,1-dioxide
- 6-chloro-7-sulfamoyl-3-benzylthiomethyl-2h-1,2,4-benzothiadiazine 1,1-dioxide
- aquatag
- aquatag
- benzothiazide
- benzothiazide
- benzothiazide
- benzothiazide
- benzotiazida
- benzotiazida
- benzthiazid
- benzthiazid
- benzthiazide
- benzthiazide
- benzthiazide
- benzthiazide
- benzthiazide
- benzthiazide
- benzthiazide
- benzthiazide
- benzthiazide
- benzthiazide
- benzthiazidum
- benzthiazidum
- benztiazide
- benztiazide
- dihydrex
- exna
- exna
- fovane
- fovane
- fovane
- lemazide
- urese
- urese