amrinone
Trade name: inocor
Approved
Jul 31, 1984
Inamrinone (Amrinone) is a positive inotropic cardiotonic with vasodilator properties, phosphodiesterase inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell. Inamrinone is a phosphodiesterase inhibitor (PDE3), resulting in increased cAMP and cGMP which leads to an increase in the calcium influx like that caused by beta-agonists resulting in increased inotropic effect. Inamrinone is used in the treatment of congestive heart failure. — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 5 marketing orgs
Timeline
1980s
- Jul 31, 1984
Sanofi-Aventis — Earliest FDA Approval
- Jul 31, 1984
Sanofi-Aventis — NDA Secondary Org
- Jul 31, 1984
Sanofi-Aventis — NDA Organization
1990s
- Aug 3, 1998
Hospira — Marketing Organization
2000s
- May 9, 2000
West-Ward Pharmaceutical — Marketing Organization
- May 9, 2000
Hikma — Marketing Organization
- May 10, 2000
Baxalta — Marketing Organization
Indications
Approved for
Mechanism of action
- Phosphodiesterase 3AINHIBITOR
PDE3A inhibitor
Approval history
- approvedJul 31, 1984
Chemistry & pharmacology
SMILES
Nc1cc(-c2ccncc2)c[nH]c1=O- Mol. weight
- 187.2 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
- Delivery
- Parenteral
- Availability
- Prescription Only
Oral
No
Parenteral
Yes
Topical
No
Sources
- ChEMBLCHEMBL12856 ↗
- WikipediaAmrinone ↗
- NCATSJUT23379TN ↗
- ChEMBLCHEMBL2096642 ↗
Also known as
- amcoral
- amcoral
- amrinona
- amrinona
- amrinone
- amrinone
- amrinone
- amrinone
- amrinone
- amrinone
- amrinone
- amrinone lactate
- amrinone lactate
- amrinone lactate
- amrinonum
- amrinonum
- cartonic
- cordemcura
- inamrinone
- inamrinone
- inamrinone
- inamrinone
- inamrinone lactate
- inamrinone lactate
- inamrinone lactate
- inamrinone lactate
- inamrinone lactate
- inamrinone lactate
- inamrinone lactate
- inocor
- inocor
- vesistol
- win-40680
- win-40680
- wincoram
Organizations
Marketing (6)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| Baxalta | For profit | MKTG | May 10, 2000 |
| Hikma | For profit | MKTG | May 9, 2000 |
| Hospira | For profit | MKTG | Aug 3, 1998 |
| Sanofi-Aventis | For profit | NDA2 | Jul 31, 1984 |
| Sanofi-Aventis | For profit | NDA | Jul 31, 1984 |
| West-Ward Pharmaceutical | For profit | MKTG | May 9, 2000 |