quinoleine
Small moleculeexperimental
Dimethisoquin (also known as Quinisocaine and QUOTANE) is a topical anesthetic used as an antipruritic. It was shown that dimethisoquin inhibits nicotinic acetylcholine receptors (alpha4/beta4 and alpha4/beta2) with the maximum inhibition potency occurring for the α4β4 subtype. — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0
Indications
Approved for
Chemistry & pharmacology
Loading structure…
SMILES
CCCCc1cc2ccccc2c(OCCN(C)C)n1- Mol. weight
- 272.39 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL127643 ↗
- NCATS772EN3BH6I ↗
- ChEMBLCHEMBL1533364 ↗
Also known as
- 3-butyl-1-(2-dimethylaminoethoxy)isoquinoline
- dimethisoquin
- dimethisoquin
- dimethisoquin
- dimethisoquin
- dimethisoquin hcl
- dimethisoquin hydrochloride
- dimethisoquin hydrochloride
- dimethisoquin monohydrochloride, monohydrate
- isochinol
- quinisocain
- quinisocaine
- quinisocaine
- quinisocaine
- quinisocaine hydrochloride
- quinisocaine hydrochloride
- quinisocaine hydrochloride
- quinisocaine hydrochloride
- quinoleine
- quotane
- quotane
- quotane