trichlorobutanol
Chlorobutanol, or trichloro-2-methyl-2-propanol, is an analgesic and sedative hypnotic in man, and an experimental general anesthetic. It has antibacterial and antifungal properties. It is also used chemical preservative for parenteral drugs. It was found, that chlorobutanol inhibited mammalian Nav 1.2 channels at concentrations less than those used to preserve parenteral solutions. Its mechanism of inhibiting Na channels differs from that of local anesthetics in that it does not show use dependent or state dependent inhibition. — NCATS
Clinical trial activity
2 trials · 2 clinical orgs · 0 marketing orgs
Earliest trial started Sep 1, 2008 (NCT00765635)
Timeline
No events for the selected filters.
Indications
Approved for
Mechanism of action
- Unspecified targetOTHER
Unknown
Chlorobutanol is a chemical preservative, sedative hypnotic and weak local anaesthetic similar in nature to chloral hydrate. It has antibacterial and antifungal properties.
Chemistry & pharmacology
SMILES
CC(C)(O)C(Cl)(Cl)Cl- Mol. weight
- 177.457 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- Yes
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- NCATSHM4YQM8WRC ↗
- ChEMBLCHEMBL1439973 ↗
Also known as
- acetochlorone
- acetonchloroform
- acetone chloroform
- chlorbutanol
- chlorbutanol
- chlorbutanol
- chlorbutol
- chlorbutol
- chlorbutol
- chloreton
- chloretone
- chloretone
- chloretone
- chloretone
- chloretone
- chlorobutanol
- chlorobutanol
- chlorobutanol
- chlorobutanol
- chlorobutanol
- chlorobutanol
- chlorobutanol
- chlorobutanol
- chlorobutanol
- trichlorisobutylalcohol
- trichlorisobutylalcohol
- trichlorobutanol
- trichlor-tertiary-butyl-alcohol
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT01115049 | Phase 4 | Feb 1, 2010 | University of Naples Frederico II |
| NCT00765635 | Phase 4 | Sep 1, 2008 | University of Barcelona |
Organizations
Research & Development (2)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| University of Barcelona | Academic/Hospital | 1 | 1 | 1 | 2008 |
| University of Naples Frederico II | Academic/Hospital | 1 | 1 | 1 | 2010 |