bithionol

Small moleculeexperimental

Bithionol is a synthetic sulfanediyl-bis-dichlorphenol), potent photosensitizer with the potential to cause serious skin disorders, formerly marketed as an active ingredient in various topical drug products. Bithionol has antibacterial and anthelmintic properties along with algaecide activity. Bithionol has been shown to be a potent inhibitor of soluble adenylyl cyclase (sAC, Adenylate cyclase type 10 ), an intracellular enzyme important in the catalysis of ATP to cAMP. Bithionol is the first known sAC inhibitor to act through the bicarbonate binding site via a mostly allosteric mechanism. Bithionol is used for treatment of tapeworm infections of dogs, cats, and poultry and for tapeworm and rumen fluke infections of sheep, horses, cattle, and goats. — NCATS

Clinical trial activity

1 trials · 1 clinical orgs · 0 marketing orgs

Phase 1

Phase 2

Phase 3

Phase 4

Earliest trial started Sep 1, 2023 (NCT06515652)

Timeline

No events for the selected filters.

Mechanism of action

Unspecified targetOTHER
Unknown
Anthelmintic drug that uncouples electron transport, acts on the mitochondrial respiratory chain and aids in the suppression of adenosine-5’-triphosphate (ATP) synthesis via uncoupling of oxidative phosphorylation.

Chemistry & pharmacology

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SMILES

OC1=C(Cl)C=C(Cl)C=C1SC2=CC(Cl)=CC(Cl)=C2O

Mol. weight: 356.052 g/mol
Lipinski Ro5: Pass
Rule of 3: No
Chirality: Single Stereoisomer
Inorganic: No
Polymer: No
Delivery: Oral
Availability: Prescription Only

Oral

Yes

Parenteral

Topical

Sources

Also known as

2,2'-dihydroxy-3,3',5,5'-tetrachlorodiphenylsulfide
2,2'-dihydroxy-3,3',5,5'-tetrachlorodiphenylsulfide
2,2'-dihydroxy-3,3',5,5'-tetrachlorodiphenyl sulfide
2,2'-dihydroxy-3,3',5,5'-tetrachlorodiphenyl sulfide
2,2'-sulfanediylbis(4,6-dichlorophenol)
2,2'-sulfanediylbis(4,6-dichlorophenol)
2,2'-thiobis (4,6-dichlorophenol)
2,2'-thiobis (4,6-dichlorophenol)
2,2'-thiobis-(4,6-dichlorophenol)
2,2'-thiobis-(4,6-dichlorophenol)
2,2'-thiobis(4,6-dichlorophenol)
2,2'-thiobis(4,6-dichlorophenol)
2,2'-thiobis[4,6-dichlorophenol]
2,2'-thiobis[4,6-dichlorophenol]
2-hydroxy-3,5-dichlorophenyl sulfide
2-hydroxy-3,5-dichlorophenyl sulfide
2-hydroxy-3,5-dichlorophenyl sulphide
2-hydroxy-3,5-dichlorophenyl sulphide
actamer
bidiphen
bis(2-hydroxy-3,5-dichlorophenyl) sulfide
bis(2-hydroxy-3,5-dichlorophenyl) sulfide
bis(3,5-dichloro-2-hydroxyphenyl) sulfide
bis(3,5-dichloro-2-hydroxyphenyl) sulfide
bisoxyphen
bithional
bithional
bithionol
bithionol
bithionol
bithionol
bithionol
bithionol
bithionol
bithionol
bithionol
bithionolate
bithionolate
bithionol sulfide
bithionol sulfide
bithionolum
bithionolum
bitionol
bitionol
bitionol
lorothidol
lorothidol
lorothidol
lorothiodol

Clinical trials

NCT ID	Phase	Start date	Sponsor(s)
NCT06515652	N/A	Sep 1, 2023	Hamdard University

Showing 1 of 1 trials

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Organizations

Research & Development (1)

Organization	Org type	Trials	As lead sponsor	Phases	Earliest year
Hamdard University	Academic/Hospital	1	1	1	2023

1 organizations

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