dicoumarol
Small moleculeapproved
Approved
Jun 1, 1944
Dicumarol is an coumarin-like compound found in sweet clover. It is used as oral anticoagulant and acts by inhibiting the hepatic synthesis of vitamin K-dependent coagulation factors (prothrombin and factors VII, IX, and X). It results in decresed prothrombin levels and a decrease in the amount of thrombin generated and bound to fibrin. This reduces the thrombogenicity of clots. Dicumarol is also used in biochemical experiments as an inhibitor of reductases. — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 2 marketing orgs
Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0
Timeline
Indications
Approved for
Mechanism of action
VKORC1 inhibitor
Approval history
- approvedJun 1, 1944
Chemistry & pharmacology
Loading structure…
SMILES
OC1=C(CC2=C(O)C3=C(OC2=O)C=CC=C3)C(=O)OC4=C1C=CC=C4- Mol. weight
- 336.295 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral
- Availability
- Discontinued
Oral
Yes
Parenteral
No
Topical
No
Sources
- WikipediaDicoumarol ↗
- NCATS7QID3E7BG7 ↗
- ChEMBLCHEMBL1466 ↗
Also known as
- 3,3'-methylen-bis(4-hydroxy-cumarin)
- 3,3'-methylen-bis(4-hydroxy-cumarin)
- 3,3'-methylenebis(4-hydroxy-1,2-benzopyrone)
- 3,3'-methylenebis(4-hydroxy-1,2-benzopyrone)
- 3,3'-methylenebis(4-hydroxy-2h-1-benzopyran-2-one)
- 3,3'-methylenebis(4-hydroxy-2h-1-benzopyran-2-one)
- 3,3'-methylenebis(4-hydroxycoumarin)
- 3,3'-methylenebis(4-hydroxycoumarin)
- 3,3'-methylene-bis(4-hydroxycoumarine)
- 3,3'-methylene-bis(4-hydroxycoumarine)
- bis-3,3'-(4-hydroxycoumarinyl)methane
- bis-3,3'-(4-hydroxycoumarinyl)methane
- bis(4-hydroxycoumarin-3-yl)methane
- bis(4-hydroxycoumarin-3-yl)methane
- bishydroxycoumarin
- bishydroxycoumarin
- bishydroxycoumarin
- bis-hydroxycoumarin
- bis-hydroxycoumarin
- di-(4-hydroxy-3-coumarinyl)methane
- di-(4-hydroxy-3-coumarinyl)methane
- dicoumal
- dicoumarin
- dicoumarol
- dicoumarol
- dicoumarol
- dicoumarol
- dicoumarol
- dicoumarol
- dicoumarol
- dicoumarol
- dicoumarolum
- dicoumarolum
- dicuman
- dicumarine
- dicumarol
- dicumarol
- dicumarol
- dicumarol
- dicumarol
- dicumarol
- dicumarol
- trombosan
- trombosan