barbital
Trade name: Veronal
Barbital, the one of the series of barbiturates, has hypnotic, sedative, and anticonvulsant properties and used under the trade name Veronal. It calmed manic patients and helped melancholic patients to sleep and was an effective inducer of sleep in insomniacs, but at the same time compound could induced dependence. It was substituted by the butyl analog, butobarbital, which was three times stronger and its period of action was much shorter due to its lipophilicity. Barbital is a ligand of GABA-receptor complex and in addition, it could have another target, a creatine kinase. — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 0 marketing orgs
Indications
Approved for
Mechanism of action
- Unspecified targetOTHER
Unknown
Barbital is a long-acting barbiturate that depresses most metabolic processes at high doses. It is used as a hypnotic and sedative and may induce dependence. Barbital is also used in veterinary practice for central nervous system depression.
Chemistry & pharmacology
SMILES
CCC1(CC)C(=O)NC(=O)NC1=O- Mol. weight
- 184.19 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL444 ↗
- WikipediaBarbital ↗
- NCATS5WZ53ENE2P ↗
- ChEMBLCHEMBL2105904 ↗
Also known as
- barbital
- barbital
- barbital
- barbital
- barbital
- barbital
- barbital sodium
- barbital sodium
- barbital sodium
- barbital sodium
- barbital sodium
- barbital sodium
- barbital, soluble
- barbital, soluble
- barbitone
- barbitone
- barbitone
- barbitone sodium
- barbitone sodium
- diemal
- diemal
- diethylbarbitone
- diethylbarbituric acid
- diethylbarbituric acid
- diethylbarbituric acid
- diethylmalonylurea
- ethylbarbital
- sodium diethylbarbiturate
- veronal
- veronal
- veronal