dithranol
Dithranol (INN) or anthralin is a hydroxyanthrone, anthracene derivative, and is used in medications applied to the skin of people with psoriasis. It is available as creams, ointment or pastes in 0.1 to 2% strengths. The terms dithranol and anthralin are sometimes used synonymously. — Wikipedia
Clinical trial activity
1 trials · 1 clinical orgs · 0 marketing orgs
Earliest trial started Nov 30, 2017 (NCT03348462)
Timeline
No events for the selected filters.
Indications
Approved for
Studied for
Mechanism of action
- Unspecified targetOTHER
Unknown
The mode of action of anthralin is thought to be either through its effect on DNA, probably mitochondrial DNA, which reduces cell turnover, or through its effects on various enzyme systems, including those of polyamine synthesis and respiration. Anthralin has been found to inhibit proliferation of keratinocytes in vivo. Oxidation of anthralin under physiological conditions results in the formation of 9-anthron-10-yl radical, a key intermediate, as well as superoxide and hydroxyl radicals. Anthralin free radicals destroy the DNA of cells and inactivate enzymes associated with cell proliferation and inflammation.
Chemistry & pharmacology
SMILES
O=C1c2c(O)cccc2Cc2cccc(O)c21- Mol. weight
- 226.23 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- Yes
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaDithranol ↗
- ChEMBLCHEMBL46469 ↗
- ChEMBLCHEMBL2108232 ↗
Also known as
- alphodith
- alphosyl
- anthra-derm
- anthra-derm
- anthralin
- anthralin
- anthralin
- anthralin
- anthralin
- anthralin
- anthralin
- antraderm
- chrysodermol
- cigthranol
- dithranol
- dithranol
- dithranol
- dithranol
- dithranol
- dithrocream
- dithrocream
- dithrocream fte
- dithrocream hp
- drithocreme
- drithocreme
- drithoscalp
- drithoscalp
- lasan
- lasan
- micanol
- micanol
- psoradrate
- psoradrate
- psorin
- psorin fte
- stie-lasan
- zetar
- zetar
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT03348462 | Phase 4 | Nov 30, 2017 | Assiut University |
Organizations
Research & Development (1)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Assiut University | Academic/Hospital | 1 | 1 | 1 | 2017 |