eugenol
Eugenol is sometimes called clove oil because it is the active element in cloves. It causes the aromatic smell typical of cloves and because of this property is often found in perfumes. Eugenol’s properties make it a good local antiseptic and analgesic. It is used in dentist offices to make zinc-oxide eugenol paste for temporary fillings. Eugenol also demonstrates antifungal and antimicrobial activity, showing efficacy against Candida albicans biofilms, Listeria monocytogenes and Escherichia coli. Eugenol is further described to induce reactive oxygen species (ROS) production and to scavenge ROS, thus demonstrating prooxidant and antioxidant effects. Also, Eugenol is used as a pesticide. — NCATS
Clinical trial activity
9 trials · 9 clinical orgs · 0 marketing orgs
Earliest trial started Jan 1, 2015 (NCT02346227)
Timeline
Indications
Approved for
Mechanism of action
- Unspecified targetUnclear
Unclear
Chemistry & pharmacology
SMILES
COC1=CC(CC=C)=CC=C1O- Mol. weight
- 164.2011 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- Yes
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaEugenol ↗
- NCATS3T8H1794QW ↗
- ChEMBLCHEMBL42710 ↗
Also known as
- allylguaiacol
- bioxeda
- caryophyllic acid
- dentogum
- eugenic acid
- eugenol
- eugenol
- eugenol
- eugenol
- eugenol
- eugenol
- eugenol
- eugenol
- eugenol
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06456060 | Phase 1 | Jun 1, 2024 | Watim Medical |
| NCT05557812 | Early Phase 1 (Phase 1) | Jan 28, 2023 | Virginia Commonwealth University |
| NCT05230797 | Early Phase 1 (Phase 1) | Apr 30, 2022 | Cairo University |
| NCT05288478 | Phase 2 | Apr 6, 2022 | Fundación Debra Chile, University of Chile |
| NCT06144983 | Phase 4 | Feb 1, 2022 | University of Baghdad |
| NCT05334745 | Phase 1 | Dec 1, 2021 | Cairo University |
| NCT03650036 | Phase 2 | Jun 4, 2018 | Federal University of Piaui |
| NCT03402321 | Phase 4 | Apr 1, 2018 | Cairo University |
| NCT02346227 | Phase 3 | Jan 1, 2015 | University of Antwerp, University of Kinshasa |
Organizations
Research & Development (9)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Cairo University | Academic/Hospital | 3 | 3 | 2 | 2018 |
| Federal University of Piaui | Academic/Hospital | 1 | 1 | 1 | 2018 |
| Fundación Debra Chile | Academic/Hospital | 1 | 0 | 1 | 2022 |
| University of Antwerp | Academic/Hospital | 1 | 1 | 1 | 2015 |
| University of Baghdad | Academic/Hospital | 1 | 1 | 1 | 2022 |
| University of Chile | Academic/Hospital | 1 | 1 | 1 | 2022 |
| University of Kinshasa | Academic/Hospital | 1 | 0 | 1 | 2015 |
| Virginia Commonwealth University | Academic/Hospital | 1 | 1 | 1 | 2023 |
| Watim Medical | Academic/Hospital | 1 | 1 | 1 | 2024 |