trypsin
Trypsin is an enzyme in the first section of the small intestine that starts the digestion of protein molecules by cutting long chains of amino acids into smaller pieces. It is a serine protease from the PA clan superfamily, found in the digestive system of many vertebrates, where it hydrolyzes proteins. Trypsin is formed in the small intestine when its proenzyme form, the trypsinogen produced by the pancreas, is activated. Trypsin cuts peptide chains mainly at the carboxyl side of the amino acids lysine or arginine. It is used for numerous biotechnological processes. The process is commonly referred to as trypsinogen proteolysis or trypsinization, and proteins that have been digested/treated with trypsin are said to have been trypsinized. — Wikipedia
Clinical trial activity
10 trials · 9 clinical orgs · 0 marketing orgs
Earliest trial started Sep 30, 1996 (NCT03470337)
Timeline
Indications
Mechanism of action
- TrypsinSupplementation
supplementation - trypsin
Chemistry & pharmacology
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaTrypsin ↗
- NCATSGV54A213NN ↗
- ChEMBLCHEMBL2108821 ↗
Also known as
- parenzyme
- trypsin
- trypsin
- trypsin
- trypsin
- trypsin
- trypsin, crystallized
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06562816 | Phase 4 | Aug 16, 2024 | Dow University of Health Sciences, Duke University |
| NCT06298383 | N/A | Mar 15, 2024 | Cairo University, Egyptian Russian University |
| NCT05681312 | Phase 3 | Oct 1, 2023 | University of Baghdad |
| NCT01433159 | Phase 2 | Sep 1, 2011 | Healthpoint |
| NCT01273428 | Phase 2 | Dec 3, 2010 | Healthpoint |
| NCT00714519 | Phase 2 | Jul 1, 2008 | Healthpoint |
| NCT00713349 | Phase 2 | Jun 1, 2008 | Healthpoint, Wake Forest University |
| NCT00645164 | Phase 1 | Mar 1, 2008 | Eurofins, Healthpoint |
| NCT00644917 | Phase 1 | Feb 1, 2008 | Healthpoint |
| NCT03470337 | Phase 3 | Sep 30, 1996 | Mucos Pharma GmbH and Co |
Organizations
Research & Development (9)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Healthpoint | For profit | 6 | 6 | 2 | 2008 |
| Cairo University | Academic/Hospital | 1 | 1 | 1 | 2024 |
| Dow University of Health Sciences | Academic/Hospital | 1 | 1 | 1 | 2024 |
| Duke University | Academic/Hospital | 1 | 0 | 1 | 2024 |
| Egyptian Russian University | Academic/Hospital | 1 | 0 | 1 | 2024 |
| Eurofins | For profit | 1 | 0 | 1 | 2008 |
| Mucos Pharma GmbH and Co | For profit | 1 | 1 | 1 | 1996 |
| University of Baghdad | Academic/Hospital | 1 | 1 | 1 | 2023 |
| Wake Forest University | Academic/Hospital | 1 | 0 | 1 | 2008 |