trypsin

Animal productexperimental

Trypsin is an enzyme in the first section of the small intestine that starts the digestion of protein molecules by cutting long chains of amino acids into smaller pieces. It is a serine protease from the PA clan superfamily, found in the digestive system of many vertebrates, where it hydrolyzes proteins. Trypsin is formed in the small intestine when its proenzyme form, the trypsinogen produced by the pancreas, is activated. Trypsin cuts peptide chains mainly at the carboxyl side of the amino acids lysine or arginine. It is used for numerous biotechnological processes. The process is commonly referred to as trypsinogen proteolysis or trypsinization, and proteins that have been digested/treated with trypsin are said to have been trypsinized. — Wikipedia

Clinical trial activity

10 trials · 9 clinical orgs · 0 marketing orgs

Phase 1
2
Phase 2
6
Phase 3
2
Phase 4
1

Earliest trial started Sep 30, 1996 (NCT03470337)

Timeline

1990s

  1. Jan 1, 1996

    Earliest Phase 3 Sponsor(trial)

2000s

  1. Jan 1, 2008

    Earliest Phase 1 Sponsor(trial)

  2. Jan 1, 2008

    Earliest Phase 2 Sponsor(trial)

Indications

Mechanism of action

Chemistry & pharmacology

Chirality
Single Stereoisomer
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • parenzyme
  • trypsin
  • trypsin
  • trypsin
  • trypsin
  • trypsin
  • trypsin, crystallized

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT06562816Phase 4Aug 16, 2024Dow University of Health Sciences, Duke University
NCT06298383N/AMar 15, 2024Cairo University, Egyptian Russian University
NCT05681312Phase 3Oct 1, 2023University of Baghdad
NCT01433159Phase 2Sep 1, 2011Healthpoint
NCT01273428Phase 2Dec 3, 2010Healthpoint
NCT00714519Phase 2Jul 1, 2008Healthpoint
NCT00713349Phase 2Jun 1, 2008Healthpoint, Wake Forest University
NCT00645164Phase 1Mar 1, 2008Eurofins, Healthpoint
NCT00644917Phase 1Feb 1, 2008Healthpoint
NCT03470337Phase 3Sep 30, 1996Mucos Pharma GmbH and Co
Showing 10 of 10 trials
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Organizations

Research & Development (9)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
HealthpointFor profit6622008
Cairo UniversityAcademic/Hospital1112024
Dow University of Health SciencesAcademic/Hospital1112024
Duke UniversityAcademic/Hospital1012024
Egyptian Russian UniversityAcademic/Hospital1012024
EurofinsFor profit1012008
Mucos Pharma GmbH and CoFor profit1111996
University of BaghdadAcademic/Hospital1112023
Wake Forest UniversityAcademic/Hospital1012008
9 organizations
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