mitumomab
mAbexperimental
Mitumomab (BEC-2) is a mouse anti-BEC-2 monoclonal antibody investigated for the treatment of small cell lung carcinoma in combination with BCG vaccination. Mitumomab attacks tumour cells, while the vaccine is thought to activate the immune system. It was developed by ImClone and Merck. — Wikipedia
Clinical trial activity
3 trials · 9 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
3
Phase 3
3
Phase 4
0
Earliest trial started Mar 1, 1998 (NCT00003279)
Timeline
1990s
- Jan 1, 1998
Earliest Phase 3 Sponsor(trial)
Indications
Mechanism of action
- Ganglioside GD3OTHER
Ganglioside GD3 other
Mitumomab is an anti-idiotypic antibody that mimics GD3, a ganglioside that is expressed on the surface of tumor cells and is of neuroectodermal origin. Induce antibodies against GD3 ganglioside.
- Ganglioside GD3Immunity, passive
Ganglioside GD3 immunity, passive
Chemistry & pharmacology
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Multi-specific
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaMitumomab ↗
- ChEMBLCHEMBL2108442 ↗
Also known as
- bec2
- bec2
- mitumomab
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT00006352 | Phase 3 | Sep 1, 1999 | European Organisation for Research and Treatment of Cancer, Leiden University |
| NCT00037713 | Phase 3 | Sep 1, 1998 | Cornell University, EORTC Lung Cancer Cooperative Group, Groupe Francais De Pneumo-Cancerologie, Imclone, Merck KGaA, Schweizerische Arbeitsgruppe fuer angewandte Krebsforschung, Spanish Lung Cancer Group |
| NCT00003279 | Phase 3 | Mar 1, 1998 | European Organisation for Research and Treatment of Cancer, Leiden University |
Showing 3 of 3 trials
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Organizations
Research & Development (9)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| European Organisation for Research and Treatment of Cancer | Academic/Hospital | 2 | 2 | 1 | 1998 |
| Leiden University | Academic/Hospital | 2 | 0 | 1 | 1998 |
| Cornell University | Academic/Hospital | 1 | 0 | 1 | 1998 |
| EORTC Lung Cancer Cooperative Group | Academic/Hospital | 1 | 0 | 1 | 1998 |
| Groupe Francais De Pneumo-Cancerologie | Academic/Hospital | 1 | 0 | 1 | 1998 |
| Imclone | For profit | 1 | 1 | 1 | 1998 |
| Merck KGaA | For profit | 1 | 0 | 1 | 1998 |
| Schweizerische Arbeitsgruppe fuer angewandte Krebsforschung | Academic/Hospital | 1 | 0 | 1 | 1998 |
| Spanish Lung Cancer Group | Academic/Hospital | 1 | 0 | 1 | 1998 |
9 organizations
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