l-serine
Small moleculeexperimental
Serine (symbol Ser or S) is an α-amino acid that is used in the biosynthesis of proteins. It contains an α-amino group, a carboxyl group, and a side chain consisting of a hydroxymethyl group, classifying it as a polar amino acid. It can be synthesized in the human body under normal physiological circumstances, making it a nonessential amino acid. It is encoded by the codons UCU, UCC, UCA, UCG, AGU and AGC. — Wikipedia
Clinical trial activity
17 trials · 19 clinical orgs · 0 marketing orgs
Phase 1
5
Phase 2
9
Phase 3
2
Phase 4
0
Earliest trial started Jan 1, 2008 (NCT00877812)
Timeline
Indications
Studied for
- Alzheimer Disease · Phase 2
- Amyotrophic Lateral Sclerosis · Phase 2
- Autism Spectrum Disorder · Phase 3
- Colorectal Neoplasms · Phase 1
- Hereditary Sensory and Autonomic Neuropathies · Phase 2
- Macula Lutea · Phase 2
- Neoplasms · Phase 1/Phase 2
- Non-alcoholic Fatty Liver Disease · Phase 1/Phase 2
- Pancreatic Neoplasms · Phase 1/Phase 2
- Vitamin B 6 Deficiency · Phase 2/Phase 3
Mechanism of action
- serineSupplementation
serine supplementation
Chemistry & pharmacology
Loading structure…
SMILES
N[C@@H](CO)C(=O)O- Mol. weight
- 105.09 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaSerine ↗
- ChEMBLCHEMBL11298 ↗
Also known as
- (2s)-2-amino-3-hydroxypropanoic acid
- (2s)-2-amino-3-hydroxypropanoic acid
- beta-hydroxyalanine
- beta-hydroxyalanine
- beta-hydroxy-l-alanine
- beta-hydroxy-l-alanine
- l-2-amino-3-hydroxypropionic acid
- l-2-amino-3-hydroxypropionic acid
- l-3-hydroxy-2-aminopropionic acid
- l-3-hydroxy-2-aminopropionic acid
- l-3-hydroxy-alanine
- l-3-hydroxy-alanine
- l-ser
- l-ser
- l-serin
- l-serin
- l-serine
- l-serine
- l-serine
- l-serine
- l-serine
- l-(-)-serine
- l-(-)-serine
- l-(−)-serine
- l-(−)-serine
- s
- s
- (s)-2-amino-3-hydroxypropanoic acid
- (s)-2-amino-3-hydroxypropanoic acid
- (s)-alpha-amino-beta-hydroxypropionic acid
- (s)-alpha-amino-beta-hydroxypropionic acid
- ser
- ser
- serine
- serine
- serine
- serine
- serine
- serine
- serine
- serine
- (s)-serine
- (s)-serine
- (s)-(-)-serine
- (s)-(-)-serine
- (s)-(−)-serine
- (s)-(−)-serine
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07178613 | Phase 1 | Nov 30, 2025 | Xinxiang Medical University |
| NCT06377631 | N/A | Jun 7, 2024 | Eurecat |
| NCT06333964 | Phase 3 | Aug 29, 2023 | Astrogen, Inc., Sungkyunkwan University |
| NCT06113055 | Phase 2 | Aug 21, 2023 | University of London |
| NCT05807204 | N/A | May 1, 2023 | Eurecat |
| NCT06245330 | Phase 1/Phase 2 (Phase 2) | Jul 7, 2022 | Ascentawits Pharmaceuticals, Ltd |
| NCT04907084 | Phase 2 | Aug 31, 2021 | The Lowy Medical Research Institute Limited |
| NCT04795960 | N/A | Mar 18, 2021 | Kenneth Rainin Foundation, University of Michigan |
| NCT04646447 | N/A | Jul 30, 2020 | Fundació Sant Joan de Déu, University of Barcelona |
| NCT03580616 | Phase 2 | Oct 31, 2018 | Brain Chemistry Labs, Institute for EthnoMedicine, Dartmouth University |
| NCT03062449 | Phase 2 | Mar 1, 2017 | Brain Chemistry Labs, Institute for EthnoMedicine, Dartmouth University |
| NCT02528994 | N/A | Sep 1, 2016 | Harvard University |
| NCT02599038 | Phase 1/Phase 2 (Phase 2) | Oct 1, 2015 | Sahlgrenska University Hospital, Sweden, University of Gothenburg |
| NCT01733407 | Phase 1/Phase 2 (Phase 2) | Sep 1, 2013 | Harvard University |
| NCT01835782 | Phase 1/Phase 2 (Phase 2) | Jan 1, 2013 | Phoenix Neurological Associates, LTD |
| NCT01128244 | Phase 2/Phase 3 (Phase 3) | Apr 1, 2010 | University of Florida |
| NCT00877812 | N/A | Jan 1, 2008 | National Institutes of Health (NIH), University of Florida |
Showing 17 of 17 trials
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Organizations
Research & Development (19)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Brain Chemistry Labs, Institute for EthnoMedicine | Academic/Hospital | 2 | 0 | 1 | 2017 |
| Dartmouth University | Academic/Hospital | 2 | 2 | 1 | 2017 |
| Eurecat | For profit | 2 | 2 | 1 | 2023 |
| Harvard University | Academic/Hospital | 2 | 2 | 2 | 2013 |
| University of Florida | Academic/Hospital | 2 | 2 | 2 | 2008 |
| Ascentawits Pharmaceuticals, Ltd | For profit | 1 | 1 | 1 | 2022 |
| Astrogen, Inc. | For profit | 1 | 1 | 1 | 2023 |
| Fundació Sant Joan de Déu | Academic/Hospital | 1 | 1 | 1 | 2020 |
| Kenneth Rainin Foundation | Academic/Hospital | 1 | 0 | 1 | 2021 |
| National Institutes of Health (NIH) | Government | 1 | 0 | 1 | 2008 |
| Phoenix Neurological Associates, LTD | Academic/Hospital | 1 | 1 | 1 | 2013 |
| Sahlgrenska University Hospital, Sweden | Academic/Hospital | 1 | 1 | 1 | 2015 |
| Sungkyunkwan University | Academic/Hospital | 1 | 0 | 1 | 2023 |
| The Lowy Medical Research Institute Limited | Academic/Hospital | 1 | 1 | 1 | 2021 |
| University of Barcelona | Academic/Hospital | 1 | 0 | 1 | 2020 |
| University of Gothenburg | Academic/Hospital | 1 | 0 | 1 | 2015 |
| University of London | Academic/Hospital | 1 | 1 | 1 | 2023 |
| University of Michigan | Academic/Hospital | 1 | 1 | 1 | 2021 |
| Xinxiang Medical University | Academic/Hospital | 1 | 1 | 1 | 2025 |
19 organizations
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