octinoxate
Approved
Dec 7, 1992
Octinoxate, also called Octyl methoxycinnamate or (OMC), is a UV filter. It can be absorbed rapidly through skin.Octinoxate filters UV‐B rays from the sun, although it does not protect against UV-A rays. Octinoxate dissolves in oil, which makes it a fat-seeking substance in the body. It is formed by combining methoxycinnamic acid and 2-ethylhexanol compounds which are not harmful on their own. When mixed together, they form a clear liquid that does not dissolve in water. Octinoxate is found in hair color products and shampoos, sunscreen, lipstick, nail polish, and skin creams. In products other than sunscreens, it is used as a UV filter to protect the products from degrading when exposed to the sun. — NCATS
Clinical trial activity
2 trials · 2 clinical orgs · 1 marketing orgs
Earliest trial started Jul 1, 2008 (NCT00530387)
Timeline
Indications
Approved for
Studied for
Mechanism of action
- Unspecified targetUltraviolet filter
ultraviolet filter
Combination products
shade uvaguar
with oxybenzone, avobenzone
Approval history
- approvedDec 7, 1992
Chemistry & pharmacology
SMILES
CCCCC(CC)COC(=O)C=Cc1ccc(OC)cc1- Mol. weight
- 290.4 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Racemic Mixture
- Inorganic
- No
- Polymer
- No
- Delivery
- Topical
- Availability
- Discontinued
Oral
No
Parenteral
No
Topical
Yes
Sources
- ChEMBLCHEMBL3183184 ↗
- WikipediaOctyl methoxycinnamate ↗
- NCATS4Y5P7MUD51 ↗
- ChEMBLCHEMBL1200608 ↗
Also known as
- 2-ethylhexyl 3-(methoxyphenyl)-2-propenoate
- 2-ethylhexyl-4-methoxycinnamate
- 2-ethylhexyl-p-methoxycinnamate
- ehmc cpd
- escalol 557
- ethylhexyl methoxycinnamate
- ethylhexyl methoxycinnamate
- ethylhexyl methoxycinnamate
- ethylhexyl methoxycinnamate
- ethylhexyl p-methoxycinnamate
- ethylhexyl p-methoxycinnamate
- ethylhexyl p-methoxycinnamate
- eusolex 2292
- heliopan new
- methoxycinnamate
- octinoxate
- octinoxate
- octinoxate
- octinoxate
- octinoxate
- octinoxate
- octinoxate
- octinoxate
- octylmethoxycinnamate
- octyl methoxycinnamate
- octyl methoxycinnamate
- octyl methoxycinnamate
- octyl methoxycinnamate
- octyl methoxycinnamate
- octyl methoxycinnamate
- octyl-methoxycinnamate
- omc cinnamate
- parsol
- parsol
- parsol
- parsol
- parsol mcx
- parsol mox
- uvinul mc80
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT01695356 | Phase 4 | Sep 1, 2012 | Universidad Autonoma de San Luis Potosi |
| NCT00530387 | N/A | Jul 1, 2008 | University of Dundee |
Organizations
Research & Development (2)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Universidad Autonoma de San Luis Potosi | Academic/Hospital | 1 | 1 | 1 | 2012 |
| University of Dundee | Academic/Hospital | 1 | 1 | 1 | 2008 |